Blood Volume Expansion Clinical Trial
Official title:
Ability of Changes in End Tidal Carbon Dioxide to Assess the Stroke Volume Effects of a Volume Expansion of 250ml of Crystalloid in the Operating Room
Volume expansion is the cornerstone of perioperative hemodynamic optimization. The main objective of volume expansion is to increase and to maximize stroke volume. Despite national and international recommendations, stroke volume monitoring is clearly not widely adopted. This is mostly due to the cost and the invasiveness of the devices allowing stroke volume monitoring. End tidal carbon dioxide is monitored in all patients undergoing general anaesthesia and is totally non-invasive. A strong relationship between stroke volume and end tidal carbon dioxide have been already demonstrated. The aim of the present study is to determine if change in End Tidal Carbon Dioxide can assess the stroke volume effects of a volume expansion of 250ml of crystalloid in the operating room
The main objective of volume expansion is to increase stroke volume. Franck-Starling curve is
schematically divided into two portions: a vertical portion which mean that an increase in
preload secondary to volume expansion will induce an increase in stroke volume; and a flat
portion which mean that a same increase in preload will not induce an increase in stroke
volume. Perioperative optimization is based on stroke volume maximization using volume
expansion. Despite national and international recommendations, stroke volume monitoring is
clearly not widely adopted. This is mostly due to the cost and the invasiveness of the
devices allowing stroke volume monitoring. End tidal carbon dioxide is monitored in all
patients undergoing general anaesthesia and is totally non-invasive. Several studies
evaluated the relationship between stroke volume and end tidal carbon dioxide and other
studies evaluated the ability of changes in end tidal carbon dioxide to assess changes in
stroke volume induced by volume expansion with discordant results. These studies included
small sample size and were heterogeneous (intensive care unit and nor operating room, volume
expansion or passive leg raising, crystalloid or colloid, 500ml and not 250 ml ….). Nowadays,
it is not clear if changes in end tidal carbon dioxide can be considered as a surrogate of
changes in stroke volume during a volume expansion in operating room patients. Thus, the aim
of the present study is to determine if change in End Tidal Carbon Dioxide can assess the
stroke volume effects of a volume expansion of 250ml of crystalloid in the operating room.
The follow up will be restricted to the duration of volume expansion. The last data will be
collected just after the end of volume expansion.
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