The Trajectory of Blood Pressure During Pregnancy in Assisted Reproductive Females

Blood Pressure Clinical Trial

Official title:

The Trajectory of Blood Pressure During Pregnancy in Assisted Reproductive Females

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT06426732
• Other study ID #: 2022-919
• Status: Recruiting
• Start date: November 1, 2022
• Est. completion date: June 30, 2025

Study information

• Verified date: May 2024
• Source: The Second Hospital of Shandong University
• Contact: Wenting Wang, M.D. Ph.D.
• Phone: +86 17660082326
• Email: 13188936075[@]163.com
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The incidence of gestational hypertension and preeclampsia in the assisted reproductive technology population during pregnancy was significantly higher than that in the general normal pregnancy population. The use of assisted reproductive technology in this population due to infertility is often accompanied by many hypertension-related factors. We established a prospective cohort study based on assisted reproductive technology pregnancy population and natural pregnancy population. Through continuous monitoring of blood pressure changes and other risk factors during pregnancy in the two groups, we explored the trajectory trend and inflection point of assisted reproductive technology pregnancy population blood pressure during pregnancy. Through factor analysis, the risk factors of elevated blood pressure during pregnancy can be clearly identified, so as to carry out early intervention and strengthen the control of risk factors of elevated blood pressure in assisted reproductive technology population, in order to expect benign maternal and infant outcomes.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 2000
• Est. completion date: June 30, 2025
• Est. primary completion date: December 31, 2024
• Accepts healthy volunteers: No
• Gender: Female
• Age group: 20 Years to 45 Years

Eligibility

Inclusion Criteria:

-Exposure group:

Mother: Seen in the obstetrics department of our hospital and meet the following conditions at the same time:

1. Complete at least one cycle of IVF or ICSI, PGD or IVM treatment (including natural cycles);

2. Clinical pregnancy was obtained after treatment. Offspring: Offspring born after in vitro fertilization-embryo transfer technique.

• Non-exposed group:

Mother: A mother who conceived naturally. Offspring: 1) Offspring born by natural pregnancy. 2) Offspring born from natural pregnancy of exposed mothers.

Exclusion Criteria:

• Unwilling to participate in this research;

• Unable to participate in this study due to special reasons, such as death, immigration, loss to follow-up;

• Hereditary diseases, mental diseases, malignant tumors, pre-pregnancy hypertension, uterine malformations and other reproductive organ malformations;

• Pregnant women who voluntarily terminate pregnancy due to non-preeclampsia factors;

Related Conditions & MeSH terms

• Blood Pressure

Locations

Country	Name	City	State
China	Cui linlin	Jinan

Sponsors (1)

Lead Sponsor	Collaborator
The Second Hospital of Shandong University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	The Trajectory of Blood Pressure During Pregnancy in Assisted Reproductive Females	The Trajectory of Blood Pressure During Pregnancy in Assisted Reproductive Females	from pregnancy to delivery