LBNP Tolerance With Skin Warming After Exercise Cold Stress

Blood Pressure Clinical Trial

Official title: Skin Rewarming After Exercise Cold Stress and Tolerance to Simulated Blood Loss

Status Recruiting

Clinical Trial Summary

Assess the effect of skin rewarming during lower body negative pressure upon arterial blood pressure and tolerance to simulated blood loss after exercise in the cold.

Clinical Trial Description

Individuals who have experienced a hemorrhagic insult are often wrapped in a warm blanket. In individuals who have exercise in a cold environment, it is unknown how this skin warming influence tolerance to simulated blood loss and whether there is an optimal temperature to warm the skin up to in order to lower blood pressure (permissive hypotension).

After an initial study visit to examine exercise capacity (Visit 1), participants will complete four trials (Visits 2 through 5) After exercise in a cold environment, participants will have cold skin temperatures (~82°F; Visit 2). Researchers will examine how increasing skin temperature to normal (~90°F; Visit 3), warm (93°F; Visit 4) and hot (95°F; Visit 5) influences arterial blood pressure and tolerance to simulated blood loss compared to when the skin remains cold.

This project will test the hypothesis that skin rewarming to ~95°F lowers arterial blood pressure without impairing tolerance to simulated blood loss (lower body negative pressure; LBNP) relative to when the skin is kept cold (82°F).

Primary data include core and skin temperatures, arterial blood pressure and LBNP tolerance time. Secondary variables include skin blood flow and heart rate. After completing visit 1 first, all participants will complete visits 2 through 5 in a randomized order and participants are blinded. The order will be counterbalanced between participants. ;

Related Conditions & MeSH terms

• Blood Loss
• Blood Pressure
• Hemorrhage

• NCT number: NCT06279897
• Study type: Interventional
• Source: University of Colorado, Colorado Springs
• Contact: James Pearson, PhD
• Phone: 7192553806
• Email: jpearso5@uccs.edu
• Status: Recruiting
• Phase: N/A
• Start date: January 24, 2022
• Completion date: September 30, 2025