Pre-conception Interventions to Reduce Blood Pressure Before Pregnancy — CONCEIVE 2  

Blood Pressure Clinical Trial

Official title: Pre-conception Interventions to Reduce Blood Pressure Before Pregnancy

Status Completed

Clinical Trial Summary

The study proposes to evaluate the feasibility of a preconception intervention comprising two proven interventions for reducing blood pressure; Beetroot juice; a source of dietary nitrate which reduces BP by 8/4mmHg after 4 weeks(6); Personalised resistance and endurance exercise programme (as per CMO recommendations) which reduces BP by ~10/5mm Hg over 8-12 weeks (7).

Clinical Trial Description

A feasibility study will be conducted for a randomised, controlled trial of preconception interventions.

The study will advertise using posters, social media and on departmental emails at Imperial College Healthcare NHS Trust or Imperial College for women aged 18-45 planning a pregnancy at any time in the future.

The study will randomise women to 1 of 4 arms Arm 1: Exercise intervention for weeks 1-12 Arm 2: Beetroot juice for weeks 1-12 Arm 3. Exercise and Beetroot juice for weeks 1-12 Arm 4: Control group

Women will be provided with daily Beetroot juice shots (as per study arm), membership to an Everybody Active centre close to their home, personal training sessions to tailor an exercise program to them (2 initial sessions then monthly), a wearable to track their physical activity and a home BP monitor. ;

Related Conditions & MeSH terms

• Blood Pressure

• NCT number: NCT05299450
• Study type: Interventional
• Source: Imperial College Healthcare NHS Trust
• Status: Completed
• Phase: N/A
• Start date: December 1, 2020
• Completion date: July 31, 2021