Acute Salt Sensitivity of Blood Pressure

Blood Pressure Clinical Trial

— AcuteSS  

Official title:

HIV Integrated Personalized Care Approach to the Prevention, Diagnosis, and Control of Salt-sensitive Hypertension: The HIPO CAP DICTSH STUDY

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04844255
• Other study ID #: PACTR202102852000433
• Status: Completed
• Phase: N/A
• Start date: December 1, 2020
• Est. completion date: February 28, 2021

Study information

• Verified date: April 2021
• Source: Mulungushi University
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Dietary salt raises blood pressure in certain individuals immediately after ingestion (acute salt sensitivity; ASS) while not affecting others. It is hypothesized that ASS is a risk factor for hypertension. However, no thresholds or diagnostic guideline is available for ASS. This study is the first aim in the main study (HIPO CAP DITSH Study) aimed at determining the threshold or blood pressure cut-offs for ASS upon ingesting dietary salt.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 132
• Est. completion date: February 28, 2021
• Est. primary completion date: February 28, 2021
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years and older

Eligibility

Inclusion Criteria:

• Adults aged 18 years and above. Normotensive. If Hypertensive (should be off antihypertensive medication at least 2 weeks prior to the study)

Exclusion Criteria:

• diabetes patients, ill participants

Related Conditions & MeSH terms

• Blood Pressure

Intervention

Dietary Supplement:
• dietary salt
2 grams of dietary salt

Locations

Country	Name	City	State
Zambia	Livingstone Central Hospital	Livingstone	Southern

Sponsors (2)

Lead Sponsor	Collaborator
Mulungushi University	University of Zambia

Country where clinical trial is conducted

Zambia, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Acute salt sensitivity	Mean arterial pressure change of 10 mmHg	160 minutes
Secondary	Diastolic blood pressure change	Diastolic blood pressure change of equal to or more than 10 mmHg	160 minutes
Secondary	Systolic blood pressure change	Systolic blood pressure change of equal to or more than 20 mmHg	160 minutes