The Effects of Dietary Salt on Post-exercise Hypotension

Blood Pressure Clinical Trial

Official title:

The Effects of Dietary Salt on Post-exercise Hypotension

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03565653
• Other study ID #: 1085139
• Status: Completed
• Phase: N/A
• Start date: May 1, 2018
• Est. completion date: July 1, 2019

Study information

• Verified date: September 2019
• Source: University of Delaware
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The new American Heart Association (AHA) blood pressure guidelines are expected to raise the prevalence of high blood pressure to ~46% in the United States. One recommendation for lowering blood pressure is aerobic exercise, which produces a period of lowered blood pressure (post-exercise hypotension; PEH) that lasts up to 24 hours. It is believed that PEH may be responsible for the observations of lowered blood pressure following initiation of exercise. However, most Americans eat too much salt, which expands plasma volume and may prevent PEH, rending aerobic exercise ineffective in improving blood pressure status.

Description:

Recently released blood pressure guidelines from the American Heart Association and American College of Cardiology are expected to raise the prevalence of hypertension in America from ~33% to ~46%. A single bout of aerobic exercise produces a prolonged period (up to 24 hours) of lowered blood pressure (post-exercise hypotension; PEH). Repeated bouts of aerobic exercise results in maintenance of lowered blood pressure, leading to recommendations of aerobic exercise for improvement of blood pressure status. However, more than 90% of Americans consume more sodium in their diets than is recommended. This is alarming, as excess dietary sodium intake expands plasma fluid volume, which may in turn attenuate the reduction in BP following exercise. Therefore, the objective of this project is to determine the effects of high dietary sodium intake on PEH. The investigators hypothesize that, compared to a recommended sodium diet, a high salt diet will attenuate post-exercise hypotension.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 20
• Est. completion date: July 1, 2019
• Est. primary completion date: June 30, 2019
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 40 Years

Eligibility

Inclusion Criteria:

• Recreationally active

Exclusion Criteria:

• high blood pressure (>140/90 mmHg)

• history of cardiovascular disease

• history of cancer

• history of diabetes

• history of kidney disease

• obesity (BMI > 30 kg/m2)

• smoking or tobacco use

• current pregnancy

• nursing mothers

• communication barriers

Related Conditions & MeSH terms

• Blood Pressure
• Hypotension
• Post-Exercise Hypotension

Intervention

Other:
• High dietary salt
~4,000 mg Na+/day
• Placebo
dextrose

Locations

Country	Name	City	State
United States	Department of Kinesiology and Applied Physiology, University of Delaware	Newark	Delaware

Sponsors (1)

Lead Sponsor	Collaborator
University of Delaware

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Post-exercise hypotension	Change in mean arterial pressure from pre- to post-exercise	24 hours following exercise
Secondary	Blood pressure reactivity	Change in mean, systolic, and diastolic blood pressure from baseline to exercise	10th day of high salt diet