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Clinical Trial Details — Status: Recruiting

Administrative data

NCT number NCT04523025
Other study ID # T197/2020
Secondary ID
Status Recruiting
Phase
First received
Last updated
Start date August 30, 2020
Est. completion date August 30, 2025

Study information

Verified date November 2020
Source Turku University Hospital
Contact Otto Ettala, MD, PhD
Phone 23130280
Email otto.ettala@tyks.fi
Is FDA regulated No
Health authority
Study type Observational [Patient Registry]

Clinical Trial Summary

Around 7200 cases of Muscle Invasive Bladder Cancer are diagnosed annually in the Nordic countries combined. Muscle Invasive Bladder Cancer is an aggressive disease and it is linked with high mortality rates. The golden standard of treatment is radical cystectomy (RC) (the surgical removal of the bladder) and radical removal of lymph nodes in the pelvis. In addition to surgical treatment, and especially in cases where the tumour invades tissues surrounding the bladder or lymph nodes, chemotherapy is recommended. Chemotherapy can be administered before or after surgery, in a neoadjuvant (NAC) or adjuvant setting (AC). Although most patients recover well from surgery, there are significant risks regarding radical cystectomy. The greatest challenges in planning the treatment are making individual risk assessments and prognosis for the treated patients. Neoadjuvant chemotherapy is also insufficiently used and it is hard to predict how the tumour responds to chemotherapy. The purpose of this study is to collect prospective clinical data on radical cystectomy -patients in co-operation with other Nordic countries: Sweden, Denmark, Iceland and Norway. The collected data is used to validate existing prediction tools and discover novel tools for prediction of morbidity related to RC and prediction of oncological outcome after RC. The study is divided into three sub-studies. The second sub-study is on the preoperative neutrophil-lymphocyte ratio (NLR). Some studies suggest that NLR might be a predictor of oncological outcome of BC after RC. In addition, NLR has been suggested to correlate with NAC response and outcome after NAC and RC. The used cut-off value for NLR has varied between 2.26-3.0. Patients will be allocated into two groups: low NLR ratio (NLR<3), and high NLR ratio (NLR≥3). The lab test will be retrieved before RC at the time of routine clinical laboratory testing for all patients and also before the initiation of NAC for patients planned to have chemotherapy. The primary end-point is bladder-cancer specific survival and, and secondary endpoints include progression-free, and overall survival.


Recruitment information / eligibility

Status Recruiting
Enrollment 230
Est. completion date August 30, 2025
Est. primary completion date August 30, 2025
Accepts healthy volunteers No
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: 1. Histologically confirmed urinary BC planned to be treated with RC with or without neoadjuvant chemotherapy. 2. Histologically confirmed urinary BC planned to be treated with palliative cystectomy 2) Signed informed consent 3) Patient age >18 years Exclusion Criteria: 1. RC for other reasons than BC 2. Other forms of surgical treatment of BC than RC (e.g. bladder resection). 3. Patient unwillingness to participate in the study for any reason (i.e. lack of signed consent).

Study Design


Intervention

Diagnostic Test:
NLR-ratio
The ratio of neutrophils and lymphocytes in patients blood sample prior to surgical operation

Locations

Country Name City State
Finland University Hospital of Turku, Hospital Distric of Southwest Finland Turku Southwest Finland

Sponsors (2)

Lead Sponsor Collaborator
Turku University Hospital Nordic Urothelial Cancer Group

Country where clinical trial is conducted

Finland, 

Outcome

Type Measure Description Time frame Safety issue
Primary Bladder-cancer specific survival 24 months
Secondary Progression-free survival 24 months
Secondary overall survival 24 months
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