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Bladder Cancer clinical trials

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NCT ID: NCT04339933 Not yet recruiting - Bladder Cancer Clinical Trials

Detection of FGFR Gene Mutations in the Tumor Tissue and Urine of Patients With Urothelial Carcinoma

Start date: May 1, 2022
Phase:
Study type: Observational

This study aims to compare the correlation between FGFR mutations found in bladder cancer tissues and urine to develop a companion diagnostic method for predicting the effect of FGFR inhibitors using urine samples of the patients with urothelial cancer.

NCT ID: NCT04305730 Not yet recruiting - Bladder Cancer Clinical Trials

Use of Pedometer Following Radical Cystectomy

Start date: March 2021
Phase: N/A
Study type: Interventional

This is a study to evaluate whether use of a pedometer following radical cystectomy decreases post-operative narcotic use and time to return of bowel function.

NCT ID: NCT04286672 Not yet recruiting - Bladder Cancer Clinical Trials

Metadherin mRNA Expression in Bladder Cancer

Start date: December 2020
Phase:
Study type: Observational

The study aims to study alterations of MTDH gene expression in the serum of bladder cancer patients compared to control group to evaluate its role as a marker for diagnosis. ,to compare the diagnostic accuracy of MTDH with the previously used marker Bladder Cancer-Specific Antigen-1 (BLCA-1 in the serum of bladder cancer patients . and to study correlation between expression of the metadherin gene and serum level of BLCA-1, and clinical and histopathological staging in patients with bladder cancer

NCT ID: NCT04245618 Not yet recruiting - Bladder Cancer Clinical Trials

Neoadjuvant Chemotherapy in Non Muscle Invasive T1b Bladder Cancer

Start date: July 2020
Phase:
Study type: Observational

The aim of our study is to evaluate the benefit of NAC in T1b NMIBC .

NCT ID: NCT04223063 Not yet recruiting - Bladder Cancer Clinical Trials

Exercise-based Pre-habilitation in Bladder Cancer Patients Prior to Radical Cystectomy: a Feasibility Study

Start date: March 2020
Phase: N/A
Study type: Interventional

The purpose of this study is to explore the feasibility and efficacy of a 12-week, home-based exercise program in bladder cancer patients undergoing curative intent neoadjuvant chemotherapy and RC.

NCT ID: NCT04219046 Not yet recruiting - Bladder Cancer Clinical Trials

Evaluation of Naloxegol in the Prevention of POI After Cystectomy

ANTAGOCYST
Start date: March 2021
Phase: Phase 2
Study type: Interventional

Postoperative ileus (POI) is defined as a transient reduction of bowel motility that prevents effective transit of bowel content and tolerance of oral intake following surgical interventions, especially after radical cystectomy. It remains a major factor associated with postoperative morbidity, length of hospital stay and medical costs. In order to optimize perioperative care for patients undergoing radical cystectomy in a context of an ERAS (Enhanced Recovery After Surgery) program, we will evaluate the effectiveness of systemic pharmacologic opioid antagonist treatment.

NCT ID: NCT04167332 Not yet recruiting - Bladder Cancer Clinical Trials

Prospective Collection of Samples for Urothelial Cancer of Bladder

ProCSUCaB
Start date: December 2019
Phase:
Study type: Observational [Patient Registry]

ProCSUCaB (Prospective Collection of Samples for Urothelial Cancer of Bladder) is a monocentric, non-interventional, prospective registry that will recruit newly diagnosed intermediate- and high-risk NMIBC patients in a tertiary center in Flanders.

NCT ID: NCT04148677 Not yet recruiting - Pain Clinical Trials

Protoves M1® Syrup in Controlling Adverse Event During HIVEC® Instillations

Start date: December 1, 2019
Phase:
Study type: Observational

100 patients with bladder cancer whose underwent Hyperthermic Intravesical Chemotherapy (HIVEC®) will be randomized in two groups (Group A: PROTOVES M1 SYRUP, Group B: NO TREATMENT). The aim of this study will be to analyse the role of two alkaloid, Protopine and Nuciferine (Protoves-M1 ®) in the prevention and the treatment of the low and mild grade adverse events related to the use of HIVEC® instillations.

NCT ID: NCT03796299 Not yet recruiting - Bladder Cancer Clinical Trials

Expression of MCM5 in Urine in Patients With Urothelial Cancers

Start date: January 2019
Phase:
Study type: Observational

In patients with non-muscle-invasive bladder cancer, the development and introduction to the clinical practice of an adequately accurate biomarker may allow to limit the indications for performing control cystoscopy. Thus, it will reduce the discomfort and stress of patients, the risk of complications of the invasive procedure and probably significantly reduce the costs incurred by healthcare systems. The aim of the present study is to determine the usefulness of the determination of MCM5 protein expression in the urine of patients with urinary bladder or upper urinary tract cancer.

NCT ID: NCT03790384 Not yet recruiting - Bladder Cancer Clinical Trials

Sequential Combination Therapy in Bladder Cancer

MITOBCG
Start date: January 15, 2019
Phase: Phase 4
Study type: Interventional

A consecutive series of patients with High Risk Non-Muscle Invasive Bladder Cancer will be enrolled in several centres. The subjects will be assessed for eligibility at the screening visit (Visit 1) three weeks after Trans-Urethral Resection of the Bladder (TURB) and re-TURB prior to randomization and only subjects who fulfil the inclusion criteria will be included. Patients selected for the study, are centrally randomized (randomization is performed at the Sant'Andrea Hospital) to receive BCG induction treatment according to the standard protocol (an instillation once a week for six weeks) with Immucyst (81 mg Connaught strain BCG). Patients in group two received BCG treatment with the same protocol with a 40 mg mitomycin instillation the day before .