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Examining Neurobiological Mechanisms Underlying the Therapeutic Effect of the Ketogenic Diet in Bipolar Disorder (BD)

Bipolar Disorder Clinical Trial

Official title:
Elucidating Neurobiological Mechanisms Underlying the Therapeutic Effect of the Ketogenic Diet in Bipolar Disorder (BD): a Multidisciplinary Mechanistic Study

Clinical Trial Summary

The investigators aim to examine the effect of the ketogenic diet on brain activity, metabolism, and emotions in adults with Bipolar Disorder (BD).

Clinical Trial Description

The investigators hypothesize that a ketogenic diet will enhance levels of the ketone body β-Hydroxybutyrate (beta OHB), resulting in reduced mania/hypomania severity and predisposition to mania/hypomania in individuals with BD. To test this hypothesis in depth, the investigators will use a novel, multidisciplinary mechanistic study using multimodal neuroimaging, peripheral markers of mitochondrial metabolism, and participant-derived induced pluripotent stem cell (iPSC)-derived organoids. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06081426
Study type Interventional
Source University of Pittsburgh
Contact Jill Morris-Tillman
Phone 412-383-8206
Email morristillmanje@upmc.edu
Status Recruiting
Phase N/A
Start date January 12, 2024
Completion date January 2027
View Details
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