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Observation of Clozapine Treatment Safety in Bipolar Disorder. — CloGD  

Bipolar Disorder Clinical Trial

Official title:
Observation of Clozapine Treatment Safety in Bipolar Disorder.

Clinical Trial Summary

The purpose of the registry is to record incidence of adverse events during treatment with clozapine in patients suffering from bipolar disorder.

Clinical Trial Description

Bipolar disorder, with its spectrum, remains a life-long and significant mental health concern due to its unpredictable nature and varied symptomatology. Despite the wide array of available treatments, some cases of bipolar disorder remain resistant to traditional medications. Clozapine, traditionally used for treatment-resistant schizophrenia, has shown promising results in managing resistant cases of bipolar disorder, particularly reducing the risk of suicide. There are not enough controlled studies on clozapine, especially in treatment resistant bipolar depression. There are certain limitations associated with the use of clozapine, primarily related to the possibility of adverse events including agranulocytosis, myocarditis, pneumonia, intestinal obstruction and seizures. Therefore, there is a need for more studies on safety and tolerability of this treatment in patients with bipolar disorder. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT06011460
Study type Observational [Patient Registry]
Source Medical University of Gdansk
Contact
Status Enrolling by invitation
Phase
Start date February 23, 2023
Completion date June 30, 2027
View Details
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