Reward and Punishment Sensitivity in Bipolar Disorders

Bipolar Disorder Clinical Trial

— Recodec-BP  

Official title:

Reward and Punishment Sensitivity in Bipolar Disorders

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT04237610
• Other study ID #: 38RC18.171
• Secondary ID: 2018-A01962-53
• Status: Recruiting
• Start date: February 24, 2020
• Est. completion date: February 23, 2022

Study information

• Verified date: September 2020
• Source: University Hospital, Grenoble
• Contact: Mircea POLOSAN, MD, PhD
• Phone: 0033476765414
• Email: mpolosan[@]chu-grenoble.fr
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Bipolar disorder (BD) represents a chronic mood disorder and one of the leading causes of disability worldwide. Complexity of its clinical presentations leads to delayed diagnosis and difficult management in routine clinical settings. Whereas distinguishing BD-I and BD-II main subtypes has a significant relevance for treatment strategy and for outcome, there are currently no clinical determinants of the BD subtype which could be used as early diagnostic predictors.

• While neurobiological specificity of each BD subtype is still controversial, available evidence suggest different dopaminergic abnormalities in each subtype. Dopaminergic function is involved in decision making and reward processing which may represent useful BD subtype markers.

• This study aims at assessing decision making during appetitive and punitive reinforcement learning in patients with BD I and BD II subtypes compared to healthy controls

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 90
• Est. completion date: February 23, 2022
• Est. primary completion date: February 23, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

• bipolar disorder (BD) type I or II, according to DSM (Diagnostic and Statistical Manual)-5 criteria

• Montgomery and Asberg Depression Rating Scale (MADRS) score < 15

• Young Mania Rating Scale (YMRS) score < 12

Exclusion Criteria:

• other main diagnosis than bipolar disorder

• other medical condition leading to cognitive deterioration

Related Conditions & MeSH terms

• Bipolar Disorder

Intervention

Behavioral:
• behavioral assessment
Probabilistic learning task

Locations

Country	Name	City	State
France	Chu Grenoble Alpes	Grenoble Cedex 9

Sponsors (1)

Lead Sponsor	Collaborator
University Hospital, Grenoble

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Response performance in reward and loss trials	percentage of correct responses in the probabilistic learning task	one day visit