fMRI of Flight of Ideas in Bipolar Disorder

Bipolar Disorder Clinical Trial

— i-TCP  

Official title:

Functional Magnetic Resonance Imaging of Formal Thought Disorders in Bipolar Disorder

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02794129
• Other study ID #: PJ12075
• Status: Completed
• Phase: N/A
• Start date: August 2013
• Est. completion date: September 2018

Study information

• Verified date: May 2016
• Source: CHU de Reims
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Bipolar disorder is a mental disease characterized by mood dysregulation and arises from manic, depressive or mixed episodes. The observations of the patient's speech and language behaviour due to flight of ideas or loss of goal probably result from an underlying disturbance in semantic networks dealing with semantic associations. The aim of our study will be to have a better comprehension of thought disorders in bipolar disorder by cognitive exploration of semantic processing.

Description:

Bipolar disorder is a mental disease characterized by mood dysregulation and arises from manic, depressive or mixed episodes. During these episodes, formal thought disorders are observed, associated to emotional perturbation, behaviour troubles and some psychotic symptoms. During mania, the type of thought disorders observed are derailment, flight of ideas, with an increase in the amount of spontaneous speech and loss of goal. These observations of the patient's speech and language behaviour probably result from an underlying disturbance in semantic networks dealing with semantic associations. These networks have been studied extensively in schizophrenia but remain unknown in bipolar disorder. In this context, the aim of our study will be to have a better comprehension of formal thought disorders in bipolar disorder by cognitive exploration of semantic activation and inhibition.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 79
• Est. completion date: September 2018
• Est. primary completion date: April 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 65 Years

Eligibility

Inclusion criteria

BD patients :

• Men or women, right-handed

• diagnosis of type 1 bipolar disorder, according to the DSM-IV criteria

• aged from 18 to 65 years-old

• Native French speaker

• Affiliated to the social security

Healthy Controls (HC):

• Men or women, right-handed

• aged from 18 to 65 years-old

• Native French speaker

• Affiliated to the social security

Exclusion criteria

BD patients :

• recent alcohol and/or drug abuse or dependence

• significant general medical illness, including neurological disorders or head trauma

• sensorial impairment (visual and/or hearing)

• Contraindication to the use of MRI

HC:

• first-degree-relative history of bipolar disorder, schizophrenia or schizoaffective disorder according to DSM-IV

• recent alcohol and/or drug abuse or dependence

• significant general medical illness, including neurological disorders or head trauma

• sensorial impairment (visual and/or hearing)

• Contraindication to the use of MRI

Related Conditions & MeSH terms

• Bipolar Disorder
• Disease

Intervention

Other:
• Functional Magnetic Resonance Imaging

Locations

Country	Name	City	State
France	Chu Reims	Reims

Sponsors (1)

Lead Sponsor	Collaborator
CHU de Reims

Country where clinical trial is conducted

France, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	brain activation profiles by Functional Magnetic Resonance Imaging		inclusion visit