Bipolar Disorder Clinical Trial
Official title:
A Study of the Acute and Chronic Effects of Electroconvulsive Therapy on Glutamatergic Neurotransmission in Bipolar Depression
The primary purpose of this study is to use magnetic resonance spectroscopy (MRS) to measure
the levels of several brain chemicals including, but not limited to, glutamate, glutamine,
and N-acetylaspartate, before and after treatment with ECT. In addition to MRS, the
investigators will use several other MRI techniques including structural MRI, resting state
functional MRI (fMRI), and diffusion tensor imaging (DTI) to measure how the structure and
function of the brain changes with ECT.
The investigators hypothesize that the Gln/Glu ratio is increased in the anterior cingulate
cortex (ACC), but not the parieto-occipital cortex (POC), following the first ECT treatment.
n/a
Observational Model: Case-Only, Time Perspective: Prospective
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