Bipolar Disorder Clinical Trial
Official title:
Memantine and Cognitive Dysfunction in Bipolar Disorder
The purpose of this study is to see whether memantine improves memory function in
participants with bipolar disorder who have minimal symptoms. Secondary analyses will test
the role of memantine in improving residual mood symptoms (depression and mania) in
participants with bipolar disorder.
We hypothesize that in participants with bipolar disorder who have minimal symptoms memantine
will be effective in improving cognitive functions, as measured by the difference in
neuropsychological test scores at the beginning and at the end of the trial.
A large proportion of participants with bipolar disorder experience significant cognitive
dysfunction, even when euthymic, after adequate treatment. The cognitive deficits in
asymptomatic patients with bipolar disorder are very important for the participant's
psychosocial function. In this population, cognitive deficits have been associated with poor
psychosocial functioning, such as inability to hold a job. Memantine is a glutamate
N-methyl-D-aspartate (NMDA) receptor antagonist which has shown efficacy in cognitive
dysfunction due to moderate to severe Alzheimer disease.
Demonstrating the role of memantine in reducing cognitive dysfunction in minimally
symptomatic participants with bipolar disorder promises to provide important clinical
information, which could lead to improvements in well-being and functional status for large
populations of participants with bipolar disorder.
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