Bipolar Disorder Clinical Trial
Official title:
Psychoeducation Versus Cognitive-Behavioral Therapy in Bipolar Disorder
To examine the impact of cognitive-behavioural therapy on both the episodic and functional
outcome of bipolar disorder, in combination with pharmacotherapy.
Primary Hypothesis is twofold:
1. Cognitive Behavioural Therapy will reduce the total symptom burden, as measured both by
percentage of time spent ill (both syndromic and subsyndromal) and number of episodes,
as compared to psychoeducation
2. Cognitive behavioural therapy will reduce social and occupational disability to a
greater extent than psychoeducation.
Objective:
To compare the impact of cognitive -behavioral therapy to that of properly structured psycho
education on the 'illness burden' and functional outcome of bipolar disorder, in combination
with pharmacotherapy.
Interventions:
Subjects will be randomized to either a "control" treatment group cosisting of 6 sessions of
group psycho-education (topics include illness recognition, treatment approaches, and
monitoring and coping strategies; based on manual by Bauer & McBride, 2002: Life Goals Phase
I) or they will be randomized to the "experimental" treatment group: 20 sessions of
individual Cognitive Behavioural Therapy for Bipolar Disorder (topics include limited
psychoeducation, activity scheduling/behavioural interventions, cognitive techniques,
including thought monitoring and challenges to dysfunctional assumptions and other coping
techniques; based on manual by Lam et al., 1999: Cognitive Therapy for Bipolar Disorder)
;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Open Label, Primary Purpose: Treatment
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