Emotion Regulation in Binge Eating and Purging Among Adolescents

Binge Eating Clinical Trial

Official title:

Neural Correlates of Emotion Regulation and Executive Function in Binge Eating and Purging Among Adolescents

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03429114
• Other study ID #: 40075
• Status: Completed
• Start date: October 15, 2017
• Est. completion date: September 1, 2022

Study information

• Verified date: December 2022
• Source: Stanford University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The study will examine the neural and behavioral correlates of emotion regulation in adolescents engaging in binge eating and/or purging and healthy adolescents. Furthermore, it will look at the influence of executive function on emotion regulation in this population. This study will allow us to gain further understanding of the neural basis of emotion regulation in this age group. Moreover, this study supports the need to develop new treatment approaches based on a better understanding of the brain processes associated with eating disorders.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 47
• Est. completion date: September 1, 2022
• Est. primary completion date: September 1, 2022
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Female
• Age group: 14 Years to 18 Years

Eligibility

Inclusion Criteria:

• Female
• Ages 14-18
• with or without current binge eating and/or purging behaviors Exclusion Criteria: We exclude patients of clinically significant low weight (<85% ideal body weight using CDC norms for height, age, and gender) and those with contraindications for MRI (e.g., orthodontia, metallic implants). Participants also will be without evidence of current or past major neurological (e.g., seizures, psychosis, head trauma) or major sensory deficit.

Related Conditions & MeSH terms

• Binge Eating
• Binge-Eating Disorder
• Bulimia
• Feeding and Eating Disorders
• Purging (Eating Disorders)

Intervention

Other:
• Magnetic resonance imaging
We will conduct MRI and fMRI brain scans to compare brain function between groups.

Locations

Country	Name	City	State
United States	Stanford University, Department of Psychiatry	Stanford	California

Sponsors (1)

Lead Sponsor	Collaborator
Stanford University

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Brain activity during emotion conflict	Functional magnetic resonance imaging will be used to measure brain activity during a task where participants respond to images of faces with emotional expressions overlaid with an emotion word written in text. We will focus on brain response during this task when emotion face vs word are in conflict.	Baseline
Primary	Brain activity during emotion regulation	Functional magnetic resonance imaging will be used to measure brain activity during a task where participants attempt to regulate emotional responses.	Baseline
Primary	Brain activity during cognitive control and emotion response	Functional magnetic resonance imaging will be used to measure brain activity during a task where participants engage in cognitive control and respond to emotional stimuli.	Baseline
Secondary	Behavioral performance on emotion conflict task	Response times will be used as behavioral measure on the emotion conflict task	Baseline
Secondary	Behavioral performance on emotion regulation task	Emotion ratings will be used as behavioral measure on the emotion regulation task	Baseline
Secondary	Behavioral performance on cognitive control and emotion regulation task	Emotion ratings will be used as behavioral measure on the cognitive control and emotion regulation task	Baseline