Gait, Stair Climbing and Postural Stability in Knee Osteoarthritis Patients After Hyaluronic Acid Injection

Bilateral Knee Osteoarthritis Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT02063373
• Other study ID #: UM/MOHE/HIR D000010-16001
• Status: Completed
• Phase: Phase 3
• First received: February 11, 2014
• Last updated: February 12, 2014
• Start date: September 2012

Study information

• Verified date: February 2014
• Source: University of Malaya
• Contact: n/a
• Is FDA regulated: No
• Health authority: Malaysia: Institutional Review Board
• Study type: Interventional

Clinical Trial Summary

Treatment: five intro-articular Hyaluronic Acid injection

Assessment has two parts, that are as follow:

1. Postural stability and risk of fall assessment using Biodex stability index and "Timed up and Go" test

2. Gait and stair climbing assessment using Vicon motion capture system synchronized with four force plates.

For knee OA subjects, assessment was done in week one or before injection; and for healthy controls one assessment was performed.

Description:

This study aimed to assess the effect of hyaluronic acid injection on Postural stability, biomechanics of gait and stair climbing in individuals with bilateral knee osteoarthritis (OA).

Participants were individuals with knee OA (control and treatment) and healthy people.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 85
• Est. primary completion date: October 2013
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 50 Years to 70 Years

Eligibility

Inclusion Criteria:

• Mild and moderate bilateral knee osteoarthritis

• Age between 50 and 70 years

Exclusion Criteria:

• Recent Lower limb injury

• Diabetic

• Knee or hip replacement

• Knees HA injection in last 6 months

• Any neuromuscular disease such as stroke and Parkinson

Study Design

Endpoint Classification: Efficacy Study, Intervention Model: Single Group Assignment, Masking: Open Label, Primary Purpose: Basic Science

Related Conditions & MeSH terms

• Bilateral Knee Osteoarthritis
• Osteoarthritis
• Osteoarthritis, Knee

Intervention

Other:
• Hyaluronic acid
treatment: Weekly intra-articular hyaluronic acid injection (20 MG / 2ML) into both knees for five weeks.

Locations

Country	Name	City	State
n/a

Sponsors (1)

Lead Sponsor	Collaborator
University of Malaya

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Change in Postural stability after treatment		baseline and 6 weeks	No
Primary	Changes in Biomechanics of gait after treatment		baseline and 6 weeks	No
Primary	Changes in biomechanics of stair climbing after treatment		baseline and 6 weeks	No
Secondary	Change in Pain after treatment		baseline and 6 weeks	No
Secondary	Changes in WOMAC scores after treatment		baseline and 6 weeks	No