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NCT05821075 Clinical Trial

Efficacy of Prednisolone Versus Cerebrolysin in the Treatment of Bell's Palsy

Bell Palsy Clinical Trial

Official title:
Comparative Study Between Prednisolone, Cerebrolysin in the Treatment of Bell's Palsy

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05821075
Other study ID # PRC-Ph-2211038
Secondary ID
Status Recruiting
Phase Phase 1/Phase 2
First received
Last updated
Start date April 24, 2023
Est. completion date December 2024

Study information
Verified date April 2024
Source October 6 University
Contact Engy Wahsh
Phone 01003095692
Email engywahsh@o6u.edu.eg
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Bell's palsy, a peripheral facial nerve paresis, is the most common disorder of the facial nerve and one of the most common mononeuropathies. Many patients with Bell's palsy will develop some complications such as synkinesis, crocodile tears and 'sweating' of the ear while eating Commonly used medications to treat Bell's palsy is Corticosteroids Cerebrolysin stimulates the regeneration of the nervous tissue with protective action we aim to study the efficacy of cerebrolycin in Bell's palsy

Recruitment information / eligibility
Status Recruiting
Enrollment 90
Est. completion date December 2024
Est. primary completion date October 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years to 60 Years
Eligibility Inclusion Criteria: - unilateral acute facial palsy of no identifiable cause Exclusion Criteria: - Recurrent facial Bell's palsy - Pregnancy - Diabetes - Epilepsy - Severe hypertension, - Renal or hepatic disease, - Gastric or duodenal ulcer - presence of acute otitis media or ipsilateral chronic otitis - Recent head injury, - psychiatric disease - If there is any contraindications for corticosteroids

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• Prednisolone
prednisolone 60mg tablet once daily for 5 days then tapering dose
• Cerebrolysin
intramuscular Cerebrolysin 10 mg daily for 3 weeks

Locations
Country Name City State
Egypt October 6 university hospital Giza

Sponsors (1)
Lead Sponsor Collaborator
October 6 University

Country where clinical trial is conducted

Egypt, 

Outcome
Type Measure Description Time frame Safety issue
Primary change in scores of the house Brackman grading system HB at baseline, after 1 week, after 3 week
Primary changes in scores of the Sunnybrook grading system. at baseline, after 1 week, after 3 week
See also
  Status Clinical Trial Phase
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Terminated NCT03996525 - Electrical Stimulation to Improve Recovery After Peripheral Nerve Injury N/A
Enrolling by invitation NCT02179684 - Surgery or Clincial Follow up, in Patients With Bell' s Palsy N/A
Not yet recruiting NCT06063954 - Two Electroacupuncture Waveforms for Different Severity Groups of Bell Palsy N/A
Completed NCT04807491 - Kabat Technique and Neuromuscular Effect in Patients With Bell's Palsy N/A
Completed NCT03592797 - Effect of Laser Acupuncture Treatment on Chronic Facial Paralysis N/A
Recruiting NCT03781700 - Evaluation of Cortisone Treatment in Children With Acute Facial Nerve Palsy Phase 4
Recruiting NCT04406376 - Do We Need to Taper Down Steroid Therapy for Bell's Palsy Phase 4
Recruiting NCT06029855 - Kabat Rehabilitation Versus Mime Therapy on Facial Disability and Synkinesis in Patients of Bell's Palsy N/A
Recruiting NCT06340009 - MIME THERAPY vs MOTOR IMAGERY TECHNIQUE in Bell's Palsy N/A
Completed NCT04280120 - Effect of Neural Mobilization in Bells Palsy: A Randomized Controlled Trial N/A
Completed NCT05891106 - AONDA Therapeutic Indication Study I
Completed NCT03974763 - Function and Form Outcomes in Patients With Facial Paralysis
Active, not recruiting NCT05997199 - The Effect Vitamin D on the Recovery Rate of Bell Palsy
Completed NCT04412733 - EFFECTİVENESS OF PULSED ULTRASOUND TREATMENT ON PATIENTS WITH BELL'S PALSY N/A
Recruiting NCT06028191 - Combined Effects of Low Level Laser Therapy and Kabat Technique in Patients With Bell's Palsy N/A
Recruiting NCT05582915 - Screening for Prognostic Biomarkers of Severe Bell's Palsy in Adults
Terminated NCT03836989 - Electrical Stimulation to Promote Recovery in Bells Palsy N/A
Recruiting NCT05270187 - Multiwave Locked System Laser for Patients With Bell's Palsy. N/A
Recruiting NCT06308250 - Comparative Effects of Mime Therapy and Action Observation Therapy in Bell's Palsy N/A