The Relationship Between Serum Levels of Angiogenin, bFGF, VEGF and Ocular Involvement in Patients With Behçet's Disease

Behçet's Disease Clinical Trial

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT01720628
• Other study ID #: AFV-5813
• Status: Completed
• Phase: N/A
• First received: October 23, 2012
• Last updated: October 31, 2012
• Start date: November 2011
• Est. completion date: February 2012

Study information

• Verified date: October 2012
• Source: Turkish Ophthalmology Society
• Contact: n/a
• Is FDA regulated: No
• Health authority: Turkey: Ethics Committee
• Study type: Observational

Clinical Trial Summary

Objectives: Behçet's disease (BD) is a systemic vasculitis. Since vascular endothelial dysfunction plays a prominent role in the pathogenesis of the disease, we considered angiogenic cytokines as an interesting target for investigation in BD. The aim of this study was to investigate the possible role of angiogenin, vascular endothelial growth factor (VEGF) and basic fibroblast growth factor (bFGF) in the pathogenesis of BD.

Design and Methods: Sixty five patients with BD and 21 healthy control subjects were included in the study. Serum angiogenin, bFGF and VEGF concentrations were determined by using in vitro enzyme immunoassay (ELISA) kits according to the manufacturer's instructions.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 86
• Est. completion date: February 2012
• Est. primary completion date: November 2011
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: Both
• Age group: 18 Years to 65 Years

Eligibility

Inclusion Criteria:

• age between 18-65

• fulfilling the international diagnostic criteria for Behçet's disease

Exclusion Criteria:

• to have another systemic disease

Study Design

Observational Model: Case Control, Time Perspective: Prospective

Related Conditions & MeSH terms

• Behcet Syndrome
• Behçet's Disease

Intervention

Other:
• serum levels of angiogenin, bFGF, VEGF
Behçet's patients

Locations

Country	Name	City	State
Turkey	Ankara University, Faculty of Medicine, Department of Ophthalmology	Ankara

Sponsors (1)

Lead Sponsor	Collaborator
Turkish Ophthalmology Society

Country where clinical trial is conducted

Turkey, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Other	Serum levels of VEGF in Behçet's patients with or without ocular involvement		1 year	No
Primary	Serum levels of angiogenin in Behçet's patients with or without ocular involvement	The median serum angiogenin level was significantly higher in all patients with BD than controls (P=0.001). However there was no statistically significant difference between all patients and patients with or without ocular involvement. The mean serum bFGF and the median serum VEGF levels were higher in patients with ocular involvement than all patients, patients without ocular involvement and controls. But these differences did not reach statistical significance.	1 year	Yes
Secondary	Serum levels of bFGF in Behçet's patients with or without ocular involvement		1 year	Yes