Behcet Disease Clinical Trial
Official title:
Possible Role of Regulatory B Cells in Behçet's Disease: Special Interest in Cardiovascular System
There are limited data about the role of regulatory B cells in Behcet Disease. In this study we aimed to identify the proportions of total B lymphocytes and their regulatory subset in different Behcet Disease phenotype and therapies concentrating on the cardiovascular system attempting to unravel their function in Behcet Disease.
Behçet's disease is a chronic multi-organ vasculitis characterized by recurrent oral and
genital aphthae, skin lesions, widespread thrombosis and aneurysmal formation, and serious
involvement of the eyes and central nervous system.
The innate and adaptive immune cells integrate in the pathogenesis of Behçet's disease.
Interestingly, the gene expression analysis of Behçet's disease patients and healthy controls
revealed the modulation of a range of genes involved in biological processes in Behçet's
disease such as inflammation, apoptosis, angiogenesis, blood coagulation, vascular damage,
signalling pathways, and immune responses, particularly, in innate immune cells, Th17 cells
and B cells. Yet, the regulatory role of B cells in Behçet's disease has not been thoroughly
investigated. Therefore, the aim of the current study is to identify the proportions of total
B lymphocytes and their regulatory subset in different Behçet's disease phenotypes and
therapies attempting to unravel their function in Behcet Disease. The role of B cells and
regulatory B cells in the cardiovascular system affection in Behcet Disease was studied in
more details.
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