Barrett's Esophagus Clinical Trial
Official title:
Racial Disparity in Barrett's Esophagus
The goal of the proposed research is to investigate the molecular mechanisms of racial
disparity in Barrett's esophagus (BE), the premalignant lesion of esophageal adenocarcinoma.
Specifically, the investigators hypothesize that environmental factors, genetic factors, and
potentially gene environment interactions play crucial roles in the observed racial
disparity in developing Barrett's esophagus.
Patients are recruited through UNC hospitals prior to scheduled esophagogastroduodenoscopy
(EGD). Participants complete a questionnaire, have body measurements obtained, and have
blood, biopsies, and gastric aspirate collected. Participants also complete a 24 hour pH
impedance test.
The goal of the proposed research is to investigate the molecular mechanisms of racial
disparity in Barrett's esophagus, the premalignant lesion of esophageal adenocarcinoma.
Specifically, the investigators hypothesize that environmental factors, genetic factors, and
potentially gene environment interactions play crucial roles in the observed racial
disparity in developing Barrett's esophagus.
Participants: Patients aged 18-80 presenting at the Gastrointestinal (Gl) Endoscopy Clinic
at UNC-Chapel Hill for elective upper endoscopy with a primary or secondary indication of
reflux symptoms.
Procedures (methods): Endoscopic biopsy, pH impedance and sampling of gastric secretions
will be performed according to our standard protocol. A series of questionnaires assessing
demographics, environmental exposure (e.g., smoking, drinking), markers of socioeconomic
status (SES), body measurement, previous health history, and gastroesophageal reflux disease
(GERD) symptomatology will be administered to our subjects.
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Observational Model: Case Control, Time Perspective: Cross-Sectional
Status | Clinical Trial | Phase | |
---|---|---|---|
Active, not recruiting |
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Completed |
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Completed |
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Suspended |
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||
Completed |
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Completed |
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Completed |
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N/A | |
Completed |
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N/A | |
Completed |
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Completed |
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Completed |
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Recruiting |
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Completed |
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Completed |
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Not yet recruiting |
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Completed |
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N/A |