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Barrett Esophagus clinical trials

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NCT ID: NCT00747136 Terminated - Barrett's Esophagus Clinical Trials

WavSTAT® Optical Biopsy System to Target Esophageal Biopsies

Start date: August 2008
Phase: N/A
Study type: Observational

The purpose of this study is to demonstrate the clinical utility of the WavSTAT Optical Biopsy System as an adjunctive tool to improve the endoscopist's clinical sensitivity to identify dysplasia or cancer in the esophagus.

NCT ID: NCT00737802 Terminated - GERD Clinical Trials

In Vivo Anatomy, Physiology, Mechanics and Function of the Lower Esophageal Sphincter

Start date: April 12, 2013
Phase:
Study type: Observational

The purpose of this study is: - To study the components of the gastroesophageal junction high-pressure zone individually and as a group, by pharmacologically eliminating or accentuating the pressure profile generated by the smooth muscle components. - To differentiate the gastric sling fibers from the clasp fibers based on the spatial orientation of these muscle groups.

NCT ID: NCT00619242 Terminated - Esophageal Cancer Clinical Trials

The Effects of Sorafenib on Molecular Barrett's Esophagus Cancer

Barrett's
Start date: June 2006
Phase: N/A
Study type: Interventional

To determine whether sorafenib is able to change pre-cancerous cells in a way that we believe is important in the progression of cancer.

NCT ID: NCT00591461 Terminated - GERD Clinical Trials

Study of Endoscopic Barrett's Esophagus Diagnosis

Start date: December 2007
Phase:
Study type: Observational

Barrett's esophagus (BE) is a condition that often occurs in patients who have had GERD for a long time. The researchers are interested in BE because it can sometimes become a cancer in the esophagus. The way that we currently diagnose BE is by performing an upper endoscopy and looking for a change in the color of the esophagus. This color change may represent BE. If the doctor sees this, he/she may take biopsies of this area. Studies have shown that making the diagnosis of BE can be hard to make. One of the reasons why this may be is because doctors may interpret what they see differently during the procedure. In other words, they may see an esophagus that appears normal in color or abnormal in color. The purpose of this study is to compare two doctors' impressions of the appearance of the esophagus during a single endoscopy procedure.

NCT ID: NCT00586404 Terminated - Clinical trials for Esophageal Neoplasms

The Study of Barrett's Esophagus: What Are the Factors of Progression

BEST
Start date: November 2007
Phase: N/A
Study type: Observational

This trial is a multi-center clinical and endoscopic outcomes project involving a single large database of patients with Barrett's Esophagus (BE). The initial goal of this project is to define the incidence and prevalence of cancer and high-grade dysplasia (HGD) in patients with BE. Thus, our hypothesis is that systematic collection of data on the natural history of BE and risk factors for progression of BE will provide useful information to develop a decision model for risk stratification and risk reduction strategies in BE.

NCT ID: NCT00576992 Terminated - Clinical trials for Gastroesophageal Reflux

Demographics and Findings of Upper Endoscopy Patients

Start date: January 2003
Phase: N/A
Study type: Observational

The purpose of this study is to evaluate the demographics, patients symptoms, and findings during endoscopy. Patients presenting for an endoscopy procedure to the KCVA GI endoscopy suite, will be asked to fill out questionnaires pertaining to their symptoms and indications for the procedure. This will be done before their procedure during the interview period preceding endoscopy. The patient's answers to this questionnaire will aid us in determining the prevalence of gastric and esophageal disease in patients presenting with the complaints of dyspepsia, GERD, or extraesophageal symptoms and to also determine whether the presence of any factors (hiatal hernia, NSAID use, age, race, gender, etc.) contribute to the above endoscopic diagnoses.

NCT ID: NCT00546065 Terminated - Barrett's Esophagus Clinical Trials

APE-Study: Ablation of Barrett's Mucosa vs. Surveillance Without Ablation in Patients Cured From Barrett's Cancer Combined With Randomization of Esomeprazole vs. Placebo for Symptomatic Reflux Control After Successful Barrett's Ablation

APE
Start date: August 2006
Phase: N/A
Study type: Interventional

This is a prospective, randomized, controlled, double-blinded, multi-center trial in a parallel-group design. Aim of the study is the evaluation of tumor-free survival after ablation (by APC, argon plasma coagulation) of Barrett's mucosa plus esomeprazole versus surveillance without ablation in patients cured from Barrett's cancer combined with randomization of esomeprazole vs placebo for symptomatic reflux control after successful ablation of Barrett's mucosa . There are two hypotheses: (1) Consecutive thermal ablation of metaplastic, non-neoplastic long segments of Barrett's esophagus (>2cm)plus esomeprazole after successful endoscopic therapy of mucosal cancer by means of ER will decrease the incidence of secondary cancer (local recurrence and metachronous cancer) by a minimum of 50% compared to acid suppression alone without ablation within a 5-years follow-up (primary endpoint). (2) After successful ablation of Barrett's esophagus patients need ongoing acid suppression therapy for medical control of their underlying reflux disease (secondary aim of the study). Duration of the study: Patient recruitment period: 3 years. Follow-up period: 5 years. Total duration: 8 years. The study is already in the recruitment period.

NCT ID: NCT00526786 Terminated - Barrett's Esophagus Clinical Trials

Study of CryoSpray Ablation of Low Grade or High Grade Dysplasia Within Barrett's Esophagus

ICE
Start date: September 2007
Phase: Phase 4
Study type: Interventional

The purpose of this study is to evaluate the safety and effectiveness of the CryoSpray Ablation System to treat esophageal low grade dysplasia (LGD) or high grade dysplasia (HGD) within Barrett's Esophagus (BE).

NCT ID: NCT00386594 Terminated - Barrett Esophagus Clinical Trials

Pilot Study of Oral 852A for Elimination of High-Grade Dysplasia in Barrett's Esophagus

Start date: October 2006
Phase: N/A
Study type: Interventional

Barrett's esophagus with high-grade dysplasia is a premalignant condition caused by chronic reflux of gastric contents into the esophagus. High-grade dysplasia is the same as carcinoma-in-situ. If untreated, patients with this condition are at high risk for developing cancer of the esophagus. Cancer of the esophagus is a miserable disease that is difficult to treat and about 95% fatal after 5 years. To prevent progession to cancer of the esophagus several interventions are available and they include surgery, Photofrin photodynamic therapy, endoscopic mucosal resection and endoscopic thermal therapy. All of these modalities are uncomfortable, expensive and have associated risks. The oral agent, 852A stimulates the innate immune system in such a way as to eliminate early cancer. A similar dermatologic drug(imiquimod) is approved for treating the premalignant condition, actinic keratosis. If local therapy with imiquimod can eliminate a premalignant lesion in the skin, a similar acting drug should be able to do the same for a premalignant lesion in the lining of the esophagus. This study is designed to test that hypothesis.

NCT ID: NCT00321958 Terminated - GERD Clinical Trials

Study of Cryotherapy Treatment of Barrett's Esophagus and Early Esophageal Cancer

Start date: April 2006
Phase:
Study type: Observational

The purpose of this study is to confirm the effectiveness and safety of a new medical device which sprays liquid nitrogen through an upper endoscope (cryotherapy) to treat Barrett's esophagus with high-grade dysplasia and early esophageal cancer. It is hypothesized that this treatment will remove the abnormal lining of the esophagus and allow the normal esophageal lining to return.