Clinical Trials Logo

Clinical Trial Summary

Bacterial vaginosis (BV) is under-reported, misdiagnosed and inappropriately treated in Nigeria. Treatment option rely on antibiotics that eliminates both good and pathogenic bacteria, with gross impact on the gut and vaginal microbiome. Our primary objective in this study is to determine the effects of Lactobacillus on the gut and vagina when taken orally.


Clinical Trial Description

Antibiotics reduces in considerable proportion both the healthy bacteria especially Lactobacilli and those associated with BV, thus the vaginal microecology and gut is adversely affected. It is widely acknowledged that Lactobacilli and other genera that produces some metabolites such as lactic acid, contributes to vaginal health by maintaining the low pH of the vagina.

The objectives of this study are three folds, first to determine the effects before and after 14 days oral feeding of Lactobacillus pentosus KCA1 on the vaginal and gut microbiota compositions of women diagnosed with BV. Second to measure the level of two proinflammatory cytokines IL-1 beta and IL-6 before and after KCA1 consumption and third to determine in silico, the relative abundance of microbial genes involved in metabolic functions using the 16S rRNA datasets. ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04329338
Study type Interventional
Source Nnamdi Azikiwe University
Contact
Status Completed
Phase N/A
Start date November 8, 2017
Completion date December 10, 2019

See also
  Status Clinical Trial Phase
Terminated NCT03954990 - Treatment of Bacterial Vaginosis Prior to Active Labor and Infectious Morbidity Phase 1
Completed NCT03837015 - Estrogen, Probiotics and Vaginal Health to Prevent HIV Infection in ACB Women Phase 1
Completed NCT03937869 - Evaluate the Safety of a Single Oral Dose of Solosecâ„¢ (Secnidazole) 2g for the Treatment of Adolescent Girls With BV Phase 4
Completed NCT03878511 - Therapeutic Lactose to Support Vaginal Microbiota N/A
Not yet recruiting NCT04846361 - Vaginal Hygiene Wash as Adjunct Treatment in Bacterial Vaginosis N/A
Completed NCT04057482 - Treatment of BV With Donaxyl and a Molecular Test of Cure
Completed NCT04393857 - The Temporo-spatial Dynamics of Genital Tract Microbiota - an Observational Study in Oocyte Donors
Completed NCT04414527 - Effects of Video-based Health Education on Maternal and Child Health in Ethiopia N/A
Recruiting NCT04807842 - Multi-Gyn ActiGel Plus for Treatment of Bacterial Vaginosis N/A
Recruiting NCT05166746 - The Effect of Clindamycin and a Live Biotherapeutic on the Reproductive Outcomes of IVF Patients With Abnormal Vaginal Microbiota Phase 2
Completed NCT04189744 - The ASPIRE Trial - Aiming for Safe Pregnancies by Reducing Malaria and Infections of the Reproductive Tract Phase 3
Recruiting NCT04517487 - Vaginal Microbiome Transplantation for Recurrent Bacterial Vaginosis N/A
Recruiting NCT04885556 - Evaluation of a Novel Female Hygiene Device for Postcoital Discomfort N/A
Terminated NCT04578015 - A Randomized Controlled Trial of Treatment of Bacterial Vaginosis Phase 4
Completed NCT06104098 - A User Study With Vernivia® for Bacterial Vaginosis. N/A