The Role of Lactate in Viral and Bacterial Infection

Bacterial Infections Clinical Trial

Official title:

The Role of Lactate From Viral to Bacterial Infection

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT04777747
• Other study ID #: lactate for infection
• Status: Completed
• Start date: January 1, 2021
• Est. completion date: March 31, 2023

Study information

• Verified date: October 2022
• Source: Daping Hospital and the Research Institute of Surgery of the Third Military Medical University
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Acute upper respiratory tract infection(AURI) is common in children, and viral infection is the main cause. However, several children with viral infection are easy to suffer from secondary bacterial infection, and the mechanism is unclear.

Description:

Lactate is an important molecule in the spread and metastasis of tumor by suppressing the innate immune response. As is known, the immune system is not mature in children and it is reverse related to the age of children. An reasonable hypothesis is that the lactate is a independent risk factor in the children with viral infection progress to bacterial infection. Here, our aim is to test the hypothesis.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 400
• Est. completion date: March 31, 2023
• Est. primary completion date: March 31, 2023
• Accepts healthy volunteers: No
• Gender: All
• Age group: 1 Minute to 18 Years

Eligibility

Inclusion Criteria:

• child's age is from 0 to 18 years

• a child is at least diagnosed with viral infection

Exclusion Criteria:

one of the following conditions appeared:

• congenital heart disease or other abnormalities

• respiratory failure

• hereditary and/or metabolic disease

Related Conditions & MeSH terms

• Bacterial Infections
• Communicable Diseases
• Hyperlactatemia
• Infections
• Lactate Blood Increase
• Viral Infection
• Virus Diseases

Intervention

Other:
• viral infection
a child is infected by virus only
• viral and bacterial infection
a child is infected by virus and progress to bacterial infection

Locations

Country	Name	City	State
China	Chen	Chongqing	Chongqing

Sponsors (2)

Lead Sponsor	Collaborator
Daping Hospital and the Research Institute of Surgery of the Third Military Medical University	Children's Hospital of Chongqing Medical University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	level of lactate	level of lactate in both viral and viral and bacterial infection groups	three days after admission
Primary	the level of lactate dehydrogenase(LDH)	level of LDH in both viral and viral and bacterial infection groups	three days after admission