B-ALL Clinical Trial
Official title:
Safety and Efficacy Study of CD22 CAR-T Cells for Relapsed or Refractory Acute Lymphoblastic Leukemia
This is an open, single-arm, clinical study to evaluate efficacy and safety of anti CD22 CAR-T cell in the treatment of recurrent or refractory B-ALL
The CARs consist of an anti-CD22 single-chain variable fragment（scFv）, a portion of the human
CD137（4-1BB） molecule, and the intracellular component of the human CD3ζ molecule. Prior to
CAR-T cell infusion, the patients will be subjected to preconditioning treatment. After CAR-T
cell infusion, the patients will be evaluated for adverse reactions and efficacy.
The Main research objectives:
To evaluate the safety and efficacy of CD22CAR-T in patients with recurrent or refractory
B-ALL
The Secondary research objectives:
To investigate the cytokinetic characteristics of CD22CAR-T in patients with recurrent or
refractory B-ALL
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