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Clinical Trial Summary

T follicular helper (TFH) cells represent a T cell subset dedicated to the activation of B cells. They have been involved in the pathogenesis of autoimmune diseases in humans such as lupus and Sjögren disease. We recently showed that TFH are implicated in the activation of autoreactive B lymphocytes during ITP. Autoimmune hemolytic anemia (AIHA) is an autoimmune disease due to antibodies targeting red blood cells. To date, the role of TFH in the pathogenesis of AIHA is not known. We hypothesize that AIHA is associated with an increase in the number and/or function of TFH, that could participate in the activation of autoreactive B lymphocytes.


Clinical Trial Description

n/a


Study Design


Related Conditions & MeSH terms


NCT number NCT02828670
Study type Observational
Source Centre Hospitalier Universitaire Dijon
Contact Sylvain AUDIA
Phone 3.80.29.34.32
Email sylvain.audia@chu-dijon.fr
Status Recruiting
Phase
Start date June 7, 2016
Completion date June 2023

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