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Autistic Disorder clinical trials

View clinical trials related to Autistic Disorder.

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NCT ID: NCT04532424 Suspended - Clinical trials for Autism Spectrum Disorder

Transcranial Magnetic Stimulation for Restricted and Repetitive Behavior in ASD

TMS for ASD
Start date: January 4, 2021
Phase: N/A
Study type: Interventional

Investigating the efficacy of a form of TMS called theta-burst stimulation for restricted and repetitive behavior in ASD.

NCT ID: NCT03866668 Suspended - Clinical trials for Autism Spectrum Disorder

A Study of Esomeprazole in Children With Autism

Start date: May 29, 2019
Phase: Phase 2
Study type: Interventional

Autism is a pervasive developmental disorder characterized by core deficits in social behavior and communication and the presence of repetitive/stereotyped behaviors. The objective of the study is to evaluate the efficacy of Esomeprazole as a treatment for social communication deficits in children with Autism Spectrum Disorder (ASD). This prospective 12 week open-label study will invite 25 children with ASD between the ages of 2 and 6 years of age to participate.

NCT ID: NCT03434366 Suspended - Clinical trials for Autism Spectrum Disorder

Intranasal Ketamine With Dexmedetomidine for the Treatment of Children With Autism Spectrum Disorder

Start date: January 20, 2018
Phase: Phase 2
Study type: Interventional

Autism spectrum disorder (ASD) is a life-long neurodevelopmental disorder characterized by qualitative abnormalities in reciprocal social interactions and patterns of communication, and by a restricted, stereotyped, repetitive repertoire of interests and activities. The use of medications in adolescents and young adults with ASD is extremely common. However, few data address the effectiveness and harms of medications specifically in this population. The purpose of the study is to determine the efficacy and safety of intranasal ketamine with dexmedetomidine in children with ASD.

NCT ID: NCT03117530 Suspended - Clinical trials for Autism Spectrum Disorder

Measuring Brain Inflammation in Autism

Start date: April 11, 2017
Phase: Phase 1
Study type: Interventional

Autism spectrum disorders (ASD) are highly disabling, persistent neurodevelopmental disorders. There are no available treatments for core symptoms of ASD or biologically-based clinical biomarkers. Emerging evidence indicates that levels of brain inflammation are increased in ASD. In particular, recent work implicates hyperactivity of microglial cells, the resident immune cells of the brain. However, the functional consequences of microglial activation remain unknown. This study will measure microglial activation in ASD using positron emission tomography (PET) brain imaging. Adult males with ASD (n=15) and healthy controls (n=15) will be recruited for this study and undergo comprehensive clinical and behavioral baseline assessment. All subjects will then undergo baseline PET imaging using a radiotracer that labels activated microglia. Subjects with ASD will then undergo 12-week open label treatment with minocycline, an FDA-approved antibiotic thought to block microglial activation. PET imaging will be repeated at 12 weeks to confirm target engagement. A subset of control subjects will also undergo repeat PET imaging to determine test-retest reliability. During minocycline treatment, ASD subjects will be evaluated every 2 weeks for safety, clinical impression, behavioral functioning, and measures of cognition. Results will provide important information regarding the relationship between levels of brain inflammation, cognitive and behavioral function in ASD.

NCT ID: NCT01435733 Suspended - Clinical trials for Autism Spectrum Disorder

Parenting a Child With Autism Spectrum Disorder and Marital Status

Start date: September 1, 2011
Phase:
Study type: Observational

The purpose of this study is to investigate whether the presence of a child with Autism Spectrum Disorder places parents at increased risk for divorce.