Autism Clinical Trial - Sensory Phenotypes of Autism Spectrum Disorder

Status Recruiting

Clinical Trial Summary

This project plans to establish sensory phenotypes of a Taiwanese ASD cohort across lifespan, including variety of sensory modalities, sensory domains, and clinical correlates. Also, we will clarify the relationship between sensory phenotypes and social impairment by two specific sensory-social paradigms targeting eye gaze avoidance and social touch anxiety, as well as the atypical neural representation of ASD during eye gaze and viewing social touch by fMRI and EEG.

Clinical Trial Description

Sensory disturbance of autism spectrum disorder (ASD) are life-long highly-impairing challenges for the individual. Anxiety and fear around the sensory issues significantly threatens the psychological and mental health. As a newly introduced diagnostic criteria of ASD, sensory characteristics becomes a recent focus of ASD research. The ASD population is aging, how their sensory features naturally change with age is particular relevant for their adaptation. However, current literature are limited to childhood and young adults and mostly rely on behavioral report, lacking a clear whole picture of changing sensory phenotype in terms of different sensory modality and sensory domains. Besides, how sensory characteristics in ASD can be quantified by objective measures or explored by qualitative approach, how the sensory sensitivity contributes to the core social deficits in ASD such as eye gaze or social touch avoidance are unclear. This project plans to achieve the following aims: 1. Establish sensory phenotypes of a Taiwanese ASD cohort across lifespan, including variety of sensory modalities (i.e., visual, tactile, auditory, smell/taste, proprioception, etc.), sensory domains (i.e., low registration, sensory seeking, sensory sensitivity, and sensory avoiding), and clinical correlates. 2. Clarify the relationship between sensory phenotypes and social impairment by two specific sensory-social paradigms targeting eye gaze avoidance and social touch anxiety, which are hallmarks of ASD. Factors of emotion types as well as familiarity of faces or social/object touch will be manipulated to examine how they moderate eye tracking and pupil response. 3. Identify the atypical neural representation of ASD during eye gaze and viewing social touch by fMRI and EEG. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT05829161
Study type	Observational
Source	National Taiwan University Hospital
Contact	Yi Ling Chien
Phone	886-2-2312-3456
Email	ylchien@hotmail.com
Status	Recruiting
Phase
Start date	January 1, 2020
Completion date	July 12, 2025

View Details

See also
Status	Clinical Trial	Phase
Active, not recruiting	`NCT05302167` - Molehill Mountain Feasibility Study.	N/A
Completed	`NCT04167839` - Effects of Sensory Diets on Children's Sensory Processing Skills, Psychosocial Skills, and Classroom Engagement	N/A
Terminated	`NCT04049981` - Investigation of Mechanisms of Action in Superpower Glass	Phase 1/Phase 2
Active, not recruiting	`NCT06080087` - Implementation Toolkit to Enhance EBP Among Marginalized Families	N/A
Recruiting	`NCT04107064` - Achieving Steady Work Among Adults With Autism Through Specialized Employment Program	N/A
Completed	`NCT03206996` - Exposure Therapy for Auditory Sensitivity in Autism	N/A
Completed	`NCT01914393` - Pediatric Open-Label Extension Study	Phase 3
Completed	`NCT05588570` - Coaching Children With Anxiety and Autism Through Telehealth	N/A
Enrolling by invitation	`NCT06058104` - Evaluating Efficacy of a Digital Game Therapeutic for Children With Autism	N/A
Completed	`NCT02911194` - a2 Milk for Autism and Attention-deficit Hyperactivity Disorder (ADHD)	N/A
Completed	`NCT02847182` - Cord Blood Infusion for Children With Autism Spectrum Disorder	Phase 2
Withdrawn	`NCT02414451` - Trial of Propranolol in Adults and Adolescents With ASD and Predictors of Response	N/A
Completed	`NCT03002363` - The Effects of Video Modeling of Audiological Testing on Pediatric Patient Compliance	Phase 1
Completed	`NCT02536365` - Sensory Integration Therapy in Autism: Mechanisms and Effectiveness	N/A
Completed	`NCT02720900` - Prebiotic Intervention for Autism Spectrum Disorders	N/A
Completed	`NCT02508922` - Trial of Vitamin D3 Supplementation in Paediatric Autism	N/A
Completed	`NCT02708290` - Mental Imagery Therapy for Autism (MITA) - an Early Intervention Computerized Language Training Program for Children With ASD
Recruiting	`NCT02255565` - Dose Response Effects of Quillivant XR in Children With ADHD and Autism: A Pilot Study	Phase 4
Recruiting	`NCT01836562` - A Clinical Trial to Study the Safety and Efficacy of Bone Marrow Derived Autologous Cells for the Treatment of Autism	Phase 1/Phase 2
Completed	`NCT02154828` - Clinical Evaluation of Integrative Practices Units Infant and Child Care for Unit Children With Typical or Atypical Autism (AUTISM)

Clinical trials are conducted in a series of steps, called phases - each phase is designed to answer a separate research question.

Phase 1: Researchers test a new drug or treatment in a small group of people for the first time to evaluate its safety, determine a safe dosage range, and identify side effects.
Phase 2: The drug or treatment is given to a larger group of people to see if it is effective and to further evaluate its safety.
Phase 3: The drug or treatment is given to large groups of people to confirm its effectiveness, monitor side effects, compare it to commonly used treatments, and collect information that will allow the drug or treatment to be used safely.
Phase 4: Studies are done after the drug or treatment has been marketed to gather information on the drug's effect in various populations and any side effects associated with long-term use.