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Autism clinical trials

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NCT ID: NCT04484077 Active, not recruiting - Clinical trials for Autism Spectrum Disorder

hCT-MSC Infusion in Adults With Autism Spectrum Disorder

AIMs
Start date: January 24, 2022
Phase: Phase 1
Study type: Interventional

The purpose of the study is to determine the safety and tolerability of a single intravenous dose of Human Umbilical Cord Tissue Derived Mesenchymal Stromal Cells (hCT-MSC) in adults with autism spectrum disorder (ASD). hCT-MSC is a cell product isolated from umbilical cord tissue. The cells from the cord tissue are processed and expanded in the laboratory and then infused intravenously in a single dose per participant. Participants will be ages 18-35 years, with ASD and a full-scale IQ >70 without an identified genetic cause of autism. Participants will have an in-person baseline visit and remote follow up visits at 6 and 12 months. In addition to the primary endpoints evaluating safety, the study will evaluate changes in social communications skills after hCT-MSC administration.

NCT ID: NCT04173663 Active, not recruiting - Clinical trials for Autism Spectrum Disorder

Advocating for Supports to Improve Service Transitions

ASSIST
Start date: January 3, 2020
Phase: N/A
Study type: Interventional

This is a randomized intervention study to develop and test the national curriculum of a parent intervention training targeting parent's ability for advocate for services to improve the transition to adulthood for their youth with autism spectrum disorder (ASD). UPDATE regarding COVID-19: Due to social distancing restrictions, the in-person intervention series that began in Winter 2020 was paused in Spring 2020 for Cohort 1 intervention groups (TN and IL). The series resumed in Summer 2020 via synchronous web-conferencing. In response to continued pandemic regulations, ASSIST was permanently moved to synchronous web-conferencing in Fall 2020, and this method was the mode of delivery for all remaining sessions and series at all sites (TN, IL, WI). The remaining baseline data was also moved to remote collection through online interview and questionnaires in Spring 2020. The data collection for all follow ups and check ins (6, 12, 18, 24, and 30 month) were completed through web conference and/or phone calls in addition to online surveys. The final data collection for experimental and control groups from all sites will be complete by Summer 2023.

NCT ID: NCT03771001 Active, not recruiting - Clinical trials for Autism Spectrum Disorder

5Minutes4Myself: A Wellness Program for Caregivers

Start date: November 2015
Phase: N/A
Study type: Interventional

This research study refines a wellness program designed for caregivers of autistic children called 5Minutes4Myself and further investigates its feasibility. Participants will attend a workshop to consent, participate in focus groups on lifestyle issues, and complete a baseline survey. Participants will have an individualized consultation with a coach to develop their tailored wellness program and be introduced to an app that support habits to build wellness activities into their daily life. The app provides the participant with their goal profile, tailored reminders, weekly check-ins, and delivers a micro-mindfulness program. Coaches will check-in monthly with participants and work together to modify their program as desired. After 4-6 months, participants will gather for a closing workshop to discuss their lifestyle and to evaluate the program. Pre-/post-surveys will examine health, well-being, stress, depression, and mindfulness. The app usability will be assessed using the Modified Systems Usability Scale (MSUS) as well as usage data.

NCT ID: NCT03690661 Active, not recruiting - Clinical trials for Autism Spectrum Disorder

Using Serious Games to Improve Social Skills in Autism

SAGA
Start date: December 1, 2019
Phase: N/A
Study type: Interventional

The investigators will conduct a small-scale randomized control trial comparing the intervention game to an active control game, and will assess outcomes at multiple time points (pre-, post-, 6-month follow-up). These outcomes will include a wide range of behaviors that are measured along a continuum from controlled lab-based tasks to uncontrolled, real-world social interactions between dyads.

NCT ID: NCT02680015 Active, not recruiting - Clinical trials for Autism Spectrum Disorder

Understanding the Effects of Intervention on the Brain in Autism

Start date: August 2010
Phase: N/A
Study type: Interventional

This study examines how the PEERS (Laugeson & Frankel, 2010; Laugeson, 2016) social-behavioral intervention affects social relationships and brain development and function in autistic preschoolers, adolescents, and young adults.

NCT ID: NCT02677051 Active, not recruiting - Clinical trials for Autism Spectrum Disorder

Sulforaphane in a New Jersey (NJ) Population of Individuals With Autism

Start date: February 2016
Phase: Phase 2
Study type: Interventional

This study is a double blind treatment trial that will test if sulforaphane improves core symptoms in autism. The investigators expect to see clinical improvement in some of these areas. Sulforaphanes come from eating certain vegetables such as broccoli. The investigators will be using a preparation that gives specific and reproducible amounts. The investigators will also test specific chemicals and genes needed for sulforaphane usage to try to understand differences in response.

NCT ID: NCT02649959 Active, not recruiting - Autism Clinical Trials

An Open Label Study of CM-AT for the Treatment of Children With Autism

Start date: October 2015
Phase: Phase 3
Study type: Interventional

This is a Phase III, open label extension study evaluating the continued safety and efficacy of CM-AT in pediatric patients with autism with all levels of fecal chymotrypsin.

NCT ID: NCT02591459 Active, not recruiting - Autism Clinical Trials

Android Mobile Devices to Assist Routine Anticipation for Autistic Children

Start date: October 2015
Phase: N/A
Study type: Interventional

The objective of this work is to develop an application to run on a mobile device Android tablet that features visual routines for autistic children.

NCT ID: NCT02430051 Active, not recruiting - Autism Clinical Trials

Sensory Adapted Dental Environments to Enhance Oral Care for Children

SADE-2
Start date: May 2015
Phase: N/A
Study type: Interventional

The goal of this project is to examine the efficacy of a sensory adapted dental environment (SADE) for children who have difficulty tolerating oral care in the dental clinic. The investigators hypothesize that adapting the sensory environment in the dental office by modifying the sounds, sights,and tactile experiences will result in decreased anxiety, increased cooperation, and fewer behavior problems for children with Autism Spectrum Disorders (ASD). This has the potential to contribute to increased child comfort as well as safer, more efficient, and less costly treatment for a large population, as potentially more than one-fourth of all children may benefit from a sensory adapted dental environment.

NCT ID: NCT02199925 Active, not recruiting - Autism Clinical Trials

An Open-Label Study to Evaluate the Efficacy of High-Dose Gammaplex in Children on the Autism Spectrum

Start date: June 2013
Phase: Phase 4
Study type: Interventional

If autism is the consequence of a chronic inflammatory process preventing the infant brain from forming the proper neural connections, then treatment that reduces inflammation might have a positive impact on autism. IGIV treatment has been known to suppress inflammation and has been used in the treatment of inflammatory conditions and autoimmune diseases.