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NCT05803005 Clinical Trial

Evaluation of Some Inflammatory Markers in Autism Spectrum Disorders

Autism Spectrum Disorder Clinical Trial

Official title:
Evaluation of Some Inflammatory Markers in Autism Spectrum Disorders

Clinical Trial Details — Status: Not yet recruiting

Administrative data
NCT number NCT05803005
Other study ID # inflammatory markers in autism
Secondary ID
Status Not yet recruiting
Phase
First received
Last updated
Start date September 1, 2023
Est. completion date October 1, 2024

Study information
Verified date March 2023
Source Assiut University
Contact ghada ali, graduated
Phone 01060012214
Email doddamohamed96@gmail.com
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

Evaluate some Inflammatory markers [IL-6, IL-8, TNF_alpha] in children with autism spectrum disorder

Description:

several studies have suggested a correlation between ASD and abnormal immune activation (9) For instance, there is a high incidence of autistic subjects in families with other autoimmune disorders such as celiac disease and rheumatoid arthritis, suggesting a potential role for immune dysfunction in the pathophysiology of ASD High levels of IL-6 in the brain could determine alterations of synapse formation, dendritic spine development, and neuronal circuit balance [13], while in plasma they have been associated with increased stereotypical behaviors and with regressive forms of ASD

Recruitment information / eligibility
Status Not yet recruiting
Enrollment 100
Est. completion date October 1, 2024
Est. primary completion date September 1, 2024
Accepts healthy volunteers
Gender All
Age group 3 Years to 18 Years
Eligibility Inclusion Criteria: - 50 patients aged 3_18 years, equally sex distributed, who visit pediatric neurology outpatients clinic with autistic disorder at assiut university hospital will enrolled in this study and 50 controls . (According to DSM IV and ADT-R) Exclusion Criteria: - : Asperger syndrome, pervasive developmental disorder not otherwise specified (PDD-NOS), chronic seizures and recent infection and patients with congenital anomalies

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• inflammatory marker in autism spectrum disorder
Evaluate some Inflammatory markers [IL-6, IL-8, TNF_alpha] in children with autism spectrum disorder

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
Assiut University

Outcome
Type Measure Description Time frame Safety issue
Primary inflammatory marker in autism Evaluate some Inflammatory markers [IL-6, IL-8, TNF_alpha] in children with autism spectrum disorder baseline
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