pBFS Guided Precision Neuromodulation Treatment for ASD

Status Recruiting

Clinical Trial Summary

This study aims to evaluate the neuromodulation (i.e., iTBS) effectiveness for treating autism spectrum disorder (ASD) by targeting at the pBFS-guided executive function brain network or social brain network.

Clinical Trial Description

Autism spectrum disorder is characterized by executive function deficiency and social interaction difficulty. Using the developed technique, personalized brain functional sectors (pBFS), we could precisely identify individualized brain function networks based on the resting-state functional MRI scan. A tailored dorsal lateral prefrontal cortex (DLPFC) region situated within the executive function network and a tailored dorsal medial prefrontal cortex (DMPFC) region situated within the social network will be selected as intervention targets. The participants will be equally randomized to the following three groups, active iTBS to the left DLPFC, active iTBS to the left DMPFC, and sham iTBS to either the left DLPFC or left DMPFC at a ratio of 2:2:1:1. Each participant will receive 1800 pulse active or sham iTBS (100% RMT) in each session, 3 sessions daily, 5 days per week for 8 weeks, as well as background behavioral training between iTBS sessions. ;

Study Design

Related Conditions & MeSH terms

Autism Spectrum Disorder

Clinical Trial Details

NCT number	NCT05735262
Study type	Interventional
Source	Changping Laboratory
Contact	Qi Liu
Phone	010-80726688
Email	a0000153@cpl.ac.cn
Status	Recruiting
Phase	N/A
Start date	March 7, 2023
Completion date	January 1, 2025

View Details

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