Cerebellar Transcranial Direct Current Stimulation (tDCS) in Children With Autism Spectrum Disorder: Raynor Cerebellum Project

Autism Spectrum Disorder Clinical Trial

Official title:

Right Lateralized Posterior Cerebellar tDCS in Children With Autism Spectrum Disorder

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05691283
• Other study ID #: STU-2022-0689
• Status: Recruiting
• Phase: N/A
• Start date: June 20, 2023
• Est. completion date: June 30, 2025

Study information

• Verified date: October 2023
• Source: University of Texas Southwestern Medical Center
• Contact: Amy Magallanes
• Phone: 214-648-5155
• Email: Amy.Magallanes[@]UTSouthwestern.edu
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

The purpose of this research study is to investigate the effects of transcranial direct current stimulation (tDCS) on some of the challenges faced by children with Autism Spectrum Disorder (ASD).

Description:

The study will be randomized, double-blind, within subject crossover design. It will involve a group of 30-40 children and young adults with Autism Spectrum Disorder (ASD). We may recruit up to 60 subjects. Diagnosis of ASD will be confirmed with the Autism Diagnostic Interview-Revised (ADI-R) or Autism Diagnostic Observation Schedule-2 (ADOS-2) by a research-reliable clinician. Each participant will undergo a sham condition and a transcranial direct current stimulation (tDCS) condition, the order of sham and tDCS conditions will be randomly assigned to each participant during baseline testing. Sham refers to participants only receiving 1 milliamp of tDCS stimulation for 1 minute, and tDCS stimulation refers to 20 minutes of tDCS stimulation. The study involves an initial screening visit followed by two sessions with three months between each session period. Each session includes the following: pre-testing and imaging, tDCS 3-week session, post-testing and imaging. Participants will complete an initial screening to confirm clinical diagnosis of ASD, determine baseline cognitive functioning, and complete a practice Magnetic Resonance Imaging (MRI) and Magnetoencephalography (MEG) session. At pre-testing, they will complete a psychometric battery, as well as undergo safety screening, and an MRI and/or MEG. Each 3-week tDCS sessions will be randomized, and each participant will undergo three weeks of sham stimulation and three weeks of 20-minute tDCS stimulation. Neither the researchers nor the participants will know which group they are assigned during each three-week session.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 60
• Est. completion date: June 30, 2025
• Est. primary completion date: June 30, 2025
• Accepts healthy volunteers: No
• Gender: All
• Age group: 5 Years to 21 Years

Eligibility

Inclusion Criteria:

• Ages 5 to 21, male and female, with known autism spectrum disorder as diagnosed by a clinician

Exclusion Criteria:

• Pregnancy

• Brain implants

• Pacemakers

• Any biomedical or metal implants in any part of body

• Hearing or visual impairment

• History of brain injury

• Known brain or skull abnormality other than those that may be associated with ASD

Related Conditions & MeSH terms

• Autism Spectrum Disorder
• Autistic Disorder
• Child Development Disorders, Pervasive

Intervention

Device:
• trans cranial direct current stimulation (tDCS)
Three weeks of 20-minute tDCS stimulation
• Sham
Three weeks of sham stimulation

Locations

Country	Name	City	State
United States	UT Southwestern Medical Center	Dallas	Texas

Sponsors (1)

Lead Sponsor	Collaborator
University of Texas Southwestern Medical Center

Country where clinical trial is conducted

United States, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Social behavior as measured by Reading the Mind in the Eyes (RME) Child Version	Reading the Mind in the Eyes (RME) Child Version will be used to measure complex mental state recognition. This test consists of 28 photographs of the eye region of the human face, each surrounded by four words. Participants pick the word that best describes what the person in the photo is thinking or feeling. Scores range from 0-28, higher score indicates very accurate at decoding a person's facial expressions around their eyes.	Baseline
Primary	Social behavior as measured by Reading the Mind in the Eyes (RME) Child Version	Reading the Mind in the Eyes (RME) Child Version will be used to measure complex mental state recognition. This test consists of 28 photographs of the eye region of the human face, each surrounded by four words. Participants pick the word that best describes what the person in the photo is thinking or feeling. Scores range from 0-28, higher score indicates very accurate at decoding a person's facial expressions around their eyes.	Post Treatment (approx at 3 month)
Primary	Social behavior as measured by Cyberball/Social Ball Throwing Task	Cyberball/Social Ball Throwing Task will be used to measure social interaction. In this task, the participant engaged in a virtual ball throwing game with two other players. There are three conditions the participants will be randomly assigned to. In two conditions participants are thrown the ball an equal number of times, in the other condition the participant is only thrown the ball a few times. After the participant completes the task, they are given a rating scale to rate how well they trust and prefer the other two players on a scale from 1-7 (totally mistrust to totally trust). The ratings indicated how well the subject was able to determine if they were left out of the group"	Baseline
Primary	Social behavior as measured by Cyberball/Social Ball Throwing Task	Cyberball/Social Ball Throwing Task will be used to measure social interaction. In this task, the participant engaged in a virtual ball throwing game with two other players. There are three conditions the participants will be randomly assigned to. In two conditions participants are thrown the ball an equal number of times, in the other condition the participant is only thrown the ball a few times. After the participant completes the task, they are given a rating scale to rate how well they trust and prefer the other two players on a scale from 1-7 (totally mistrust to totally trust). The ratings indicated how well the subject was able to determine if they were left out of the group"	Post Treatment (approx at 3 month)
Primary	Sensorimotor behavior as measured by Grip Strength	Participants grip a specially designed fiber optic device (Aither Engineering, Inc.). This device detects nanometer changes in grip force which are calibrated in Newtons. Participants are instructed to rest their arm in a relaxed position. Subjects use their thumb and index finger to press against grip device. Prior to testing, each subject will complete the maximum voluntary contraction for each hand during trials of 3 seconds each with 15 seconds in between each trial. The subject is then instructed to press as hard as they can when the screen says "go" using only the thumb and pointer finger.	Baseline
Primary	Sensorimotor behavior as measured by Grip Strength	Participants grip a specially designed fiber optic device (Aither Engineering, Inc.). This device detects nanometer changes in grip force which are calibrated in Newtons. Participants are instructed to rest their arm in a relaxed position. Subjects use their thumb and index finger to press against grip device. Prior to testing, each subject will complete the maximum voluntary contraction for each hand during trials of 3 seconds each with 15 seconds in between each trial. The subject is then instructed to press as hard as they can when the screen says "go" using only the thumb and pointer finger.	Post Treatment (approx at 3 month)
Primary	Sensorimotor behavior as measured by Reach Task	Participants will be positioned at a table with reaching arm resting on the table in a neutral position. The task includes picking up small objects placed on the table and placing the objects one by one into a target container in two trials: preferred and non-preferred hands. The task is rated on a 6-point rating scale, where 5 represents weakest performance, and 0 represents best performance. Each item is given a raw score and a standard score, which translate to a component score and percentile rank.	Baseline
Primary	Sensorimotor behavior as measured by Reach Task	Participants will be positioned at a table with reaching arm resting on the table in a neutral position. The task includes picking up small objects placed on the table and placing the objects one by one into a target container in two trials: preferred and non-preferred hands. The task is rated on a 6-point rating scale, where 5 represents weakest performance, and 0 represents best performance. Each item is given a raw score and a standard score, which translate to a component score and percentile rank.	Post Treatment (approx at 3 month)
Primary	Sensorimotor behavior as measured by Sensory Profile-2	A parent self-report form designed to assess sensory processing patterns in children and adolescents. The report includes three subscales: sensory system, behavior, and sensory pattern.Each item is scored on a Likert scale from 1 to 5 (1=Much Less Than Others, 2=Less Than Others, 3=Just Like the Majority of Others, 4=More Than Others, 5=Much More Than Others). Raw scores are totaled and converted to percentile ranks based on participant age.	Baseline
Primary	Sensorimotor behavior as measured by Sensory Profile-2	A parent self-report form designed to assess sensory processing patterns in children and adolescents. The report includes three subscales: sensory system, behavior, and sensory pattern.Each item is scored on a Likert scale from 1 to 5 (1=Much Less Than Others, 2=Less Than Others, 3=Just Like the Majority of Others, 4=More Than Others, 5=Much More Than Others). Raw scores are totaled and converted to percentile ranks based on participant age.	Post Treatment (approx at 3 month)
Primary	Neurophysiological impacts as measured by Magnetoencephalography (MEG)	MEG data will be processed using AFNI (https://afni.nimh.nih.gov/). Using all channels of the MEG data, strength and latency of responses are measured by transforming each subject's raw MEG activity into brain space. A spatial filter is applied which separates the source activity from different brain regions to observe overlap at the sensor level. This analysis will assess functional connectivity between the region of interest (ROI) voxel, the right Crus I of the cerebellum, compared to all other voxels in the brain. Seed-based voxel correlation analysis enables researchers to see the statistical correlation between the ROI activity and activity in other cortical areas. This correlation reveals patterns of connectivity between the ROI and other cortical regions. The second level analysis will utilize a one-way ANOVAs will compare baseline measures (Cyberball, Precision Grip) and demographics (e.g. age) within groups. The within subjects' effect of tDCS on task scores will be evaluated	Baseline
Primary	Neurophysiological impacts as measured by Magnetoencephalography (MEG)	MEG data will be processed using AFNI (https://afni.nimh.nih.gov/). Using all channels of the MEG data, strength and latency of responses are measured by transforming each subject's raw MEG activity into brain space. A spatial filter is applied which separates the source activity from different brain regions to observe overlap at the sensor level. This analysis will assess functional connectivity between the region of interest (ROI) voxel, the right Crus I of the cerebellum, compared to all other voxels in the brain. Seed-based voxel correlation analysis enables researchers to see the statistical correlation between the ROI activity and activity in other cortical areas. This correlation reveals patterns of connectivity between the ROI and other cortical regions. The second level analysis will utilize a one-way ANOVAs will compare baseline measures (Cyberball, Precision Grip) and demographics (e.g. age) within groups. The within subjects' effect of tDCS on task scores will be evaluated	Post Treatment (approx at 3 month)
Primary	Neurophysiological impacts as measured by functional magnetic resonance imaging (fMRI)	fMRI data will be processed using AFNI (https://afni.nimh.nih.gov/). A regression analyses is used (3dDeconvolve and 3dREML) for each subject. Data collected from MRI acquisition will be analyzed at two levels. The first level of analysis will use seed-based voxel correlational analysis, a statistical technique for observing differences in brain activity. This analysis will assess functional connectivity between the region of interest (ROI) voxel, the right Crus I of the cerebellum, compared to all other voxels in the brain. Seed-based voxel correlation analysis enables researchers to see the statistical correlation between the ROI activity and activity in other cortical areas. This correlation reveals patterns of connectivity between the ROI and other cortical regions. The second level analysis will utilize a one-way ANOVAs will compare baseline measures (Cyberball, Precision Grip) and demographics (e.g. age) within groups.	Baseline
Primary	Neurophysiological impacts as measured by functional magnetic resonance imaging (fMRI)	fMRI data will be processed using AFNI (https://afni.nimh.nih.gov/). A regression analyses is used (3dDeconvolve and 3dREML) for each subject. Data collected from MRI acquisition will be analyzed at two levels. The first level of analysis will use seed-based voxel correlational analysis, a statistical technique for observing differences in brain activity. This analysis will assess functional connectivity between the region of interest (ROI) voxel, the right Crus I of the cerebellum, compared to all other voxels in the brain. Seed-based voxel correlation analysis enables researchers to see the statistical correlation between the ROI activity and activity in other cortical areas. This correlation reveals patterns of connectivity between the ROI and other cortical regions. The second level analysis will utilize a one-way ANOVAs will compare baseline measures (Cyberball, Precision Grip) and demographics (e.g. age) within groups.	Post Treatment (approx at 3 month)
Secondary	Executive functioning as measured by Flanker Inhibitory Control and Attention	The NIH Toolbox Flanker Inhibitory Control and Attention Test measures both a participant's attention and inhibitory control. Accuracy and reaction scores range in value between 0 and 5. If accuracy scores for the participant reach more than 80%, the reaction time score and accuracy score are combined. Combined scores range in value from 0-10. This score shows how accurate and how quickly the subject responded, the high the score the more accurate and quickly each subject responded.	Baseline
Secondary	Executive functioning as measured by Flanker Inhibitory Control and Attention	The NIH Toolbox Flanker Inhibitory Control and Attention Test measures both a participant's attention and inhibitory control. Accuracy and reaction scores range in value between 0 and 5. If accuracy scores for the participant reach more than 80%, the reaction time score and accuracy score are combined. Combined scores range in value from 0-10. This score shows how accurate and how quickly the subject responded, the high the score the more accurate and quickly each subject responded.	Post Treatment (approx at 3 month)
Secondary	Executive functioning as measured by Dimensional Card Change Sort	The Dimensional Change Card Sort (DCCS) is a measure of cognitive flexibility, also known as task switching or set shifting. Scoring is based on a combination of accuracy and reaction time. Accuracy and reaction scores range in value between 0 and 5. If accuracy scores for the participant reach more than 80%, the reaction time score and accuracy score are combined. Combined scores range in value from 0-10. This score shows how accurate and how quickly the subject responded, the high the score the more accurate and quickly each subject responded.	Baseline
Secondary	Executive functioning as measured by Dimensional Card Change Sort	The Dimensional Change Card Sort (DCCS) is a measure of cognitive flexibility, also known as task switching or set shifting. Scoring is based on a combination of accuracy and reaction time. Accuracy and reaction scores range in value between 0 and 5. If accuracy scores for the participant reach more than 80%, the reaction time score and accuracy score are combined. Combined scores range in value from 0-10. This score shows how accurate and how quickly the subject responded, the high the score the more accurate and quickly each subject responded.	Post Treatment (approx at 3 month)
Secondary	Working memory as measured by Stanford Binet-V Working Memory Subtest	Stanford Binet-V Working Memory Subtest assesses how well the subject recalls facts and objects. This area assesses how well the subject recalls facts and objects. At lower levels, the non-verbal test involves asking the subject to find an object hidden under a cup, or block tapping in which the subject must repeat a sequence of tapping on blocks initiated by the examiner. The verbal test requires the subject to recall the last words of several sentences in a series. Raw scores are the total number of items correct and are converted into standard scores (0-119) for each subtest based on participant age. Standard scores of 100-110 are considered average for the subjects age range	Baseline
Secondary	Working memory as measured by Stanford Binet-V Working Memory Subtest	Stanford Binet-V Working Memory Subtest assesses how well the subject recalls facts and objects. This area assesses how well the subject recalls facts and objects. At lower levels, the non-verbal test involves asking the subject to find an object hidden under a cup, or block tapping in which the subject must repeat a sequence of tapping on blocks initiated by the examiner. The verbal test requires the subject to recall the last words of several sentences in a series. Raw scores are the total number of items correct and are converted into standard scores (0-119) for each subtest based on participant age. Standard scores of 100-110 are considered average for the subjects age range	Post Treatment (approx at 3 month)