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Psilocybin in Adults With and Without Autism Spectrum Disorder — PSILAUT  

Autism Spectrum Disorder Clinical Trial

Official title:
Modulation of Serotonin Pathways Using Psilocybin in Adults With and Without Autism Spectrum Disorder (ASD)

Clinical Trial Summary

This study will test the hypothesis that brain systems are differentially regulated by serotonin in individuals with and without Autism Spectrum Disorder.

Clinical Trial Description

To do this, the brain response to two single acute doses of partial serotonin (5HT)1A/2A receptor agonist psilocybin (COMP360) relative to a single dose of placebo (baseline serotonin activity) will be compared in healthy autistic and non-autistic adults. Brain function will be assessed using a range of MRI (fMRI and MRS), EEG and sensory tasks. Unimodal and multimodal analyses will be conducted. Please note that this study uses psilocybin as a probe of the serotonin system in a Case-Control science study and, following Scope protocol review, the U.K. MHRA confirmed that it is not a 'Clinical Trial of an Investigational Medicinal Product' (IMP) as defined by the EU Directive 2001/20/EC. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details
NCT number NCT05651126
Study type Interventional
Source King's College London
Contact Grainne McAlonan
Phone 00442078480002
Email mrs@kcl.ac.uk
Status Recruiting
Phase N/A
Start date December 12, 2022
Completion date September 2025
View Details
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