Development of Eye-tracking Based Markers for Autism in Young Children

Autism Spectrum Disorder Clinical Trial

Official title:

Evaluation of Five Different Eye-tracking Paradigms to Determine Autism in Young Children

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03286621
• Other study ID #: UESCT_neuSCAN_41
• Status: Completed
• Start date: September 9, 2017
• Est. completion date: February 28, 2018

Study information

• Verified date: October 2018
• Source: University of Electronic Science and Technology of China
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

The main aim of the present study is to examine eye-tracking based markers for social processing deficits in children with autism spectrum disorder (ASD). To this end a battery of five eye-tracking paradigms will be administered to young children with ASD and typically developing children. To additionally evaluate the specificity of the eye-tracking markers a group of children with disorders of delayed development other than ASD will be included.

Description:

During an initial screening session all participants will undergo the Autism Diagnostic Observation Schedule (ADOS). ASD-related symptomatology and levels of impairments will be further characterized using the Social Responsibilities Scale 2 (SRS 2), Caregiver Strain Questionnaire (CSQ), Aberrant Behavior Checklist (ABC), Social Communication Questionnaire (SCQ), and Repetitive Behaviour Scale Revised (RBS-R).

Subsequently all participants will be administered the following eye-tracking paradigms: (1) dynamic social and non-social visual preference paradigm during which dynamic geometric images (DGI) and dynamic social images (DSI) will be presented, (2) non-biological versus biological motion paradigm, (3) social attention and sharing of enjoyment paradigm, (4) preference for real versus schematic emotional face stimuli paradigm during which photographs of human faces and emoticons will be presented, (5) shared social attention and gaze direction paradigm.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 70
• Est. completion date: February 28, 2018
• Est. primary completion date: February 28, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 12 Months to 10 Years

Eligibility

Exclusion criteria for all participants:

• visual, auditory or motor impairments

• use of medication

Inclusion criteria for all participants:

• written informed consent from parents / caregiver

• age: 1-10 years

Additional inclusion criterion for the ASD group:

• diagnosis of Autism Spectrum Disorder according to DSM-5

Additional inclusion criteria for typically developing children in the control group:

• no symptoms of developmental disorders

• no current or history of psychological disorder

Additional inclusion criterion for the unspecific disorder of delayed development children in the additional control group:

• disorder of delayed development other than ASD

Related Conditions & MeSH terms

• Autism Spectrum Disorder
• Autistic Disorder

Intervention

Other:
• Administration of five eye-tracking paradigms
All subjects will undergo the battery of five eye-tracking paradigms to determine potential markers for autism.

Locations

Country	Name	City	State
China	School of Life Science and Technology, University of Electronic Science and Technology of China	Chengdu	Sichuan

Sponsors (1)

Lead Sponsor	Collaborator
University of Electronic Science and Technology of China

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Global eye-gaze characteristics	Global eye-gaze patterns between the three groups will be compared to determine ASD specific alterations	Single assessment, total duration 20 minutes
Primary	Feature-specific eye-gaze characteristics	Localized feature-specific eye-gaze patterns will be compared between the three groups to determine ASD specific alterations	Single assessment, total duration 20 minutes
Secondary	Global eye-gaze characteristics and associations with symptom severity	Associations between global eye-gaze characteristics and severity of ASD symptoms	Single assessment, total duration 20 minutes
Secondary	Feature-specific eye-gaze characteristics and associations with symptom severity	Associations between localized feature-specific eye-gaze patterns and severity of ASD symptoms	Single assessment, total duration 20 minutes