Autism Spectrum Disorder Clinical Trial
Official title:
Repetitive Transcranial Magnetic Stimulation (rTMS) for Executive Function Deficits in Autism Spectrum Disorder and Effects on Brain Structure: A Pilot Study
NCT number | NCT02311751 |
Other study ID # | 119/2013 |
Secondary ID | |
Status | Completed |
Phase | N/A |
First received | |
Last updated | |
Start date | October 2014 |
Est. completion date | May 4, 2018 |
Verified date | March 2019 |
Source | Centre for Addiction and Mental Health |
Contact | n/a |
Is FDA regulated | No |
Health authority | |
Study type | Interventional |
In this study, the investigators will be examining the effects of repetitive transcranial magnetic stimulation (rTMS) on executive function deficits in individuals with autism spectrum disorder. Half of the participants will be chosen by chance to receive active rTMS stimulation while half will be chosen by chance to receive sham rTMS. Sham rTMS will feel the same as active rTMS only there will be no direct brain stimulation. This is necessary to ensure that active rTMS is efficacious in the enhancement of executive function in individuals with autism spectrum disorder. Based on results from a recently published pilot study, the investigators propose that active rTMS treatment will result in a significant improvement in working memory performance compared to sham rTMS treatment.
Status | Completed |
Enrollment | 40 |
Est. completion date | May 4, 2018 |
Est. primary completion date | May 4, 2018 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | All |
Age group | 16 Years to 35 Years |
Eligibility |
Inclusion Criteria Autism Spectrum Disorder (ASD): - Are fluent in the English language - Have a diagnosis of high functioning ASD (HF-ASD) (i.e., are verbal with an Intelligence Quotient (IQ) = 70) - Are competent to consent based on the subjects' ability to provide a spontaneous narrative description of the key elements of the study - Are clinically stable as determined by their treating physician, with no medication changes over the past 4 weeks Exclusion Criteria (ASD): - Have a history of substance abuse or dependence in the last 6 months or have a positive urine toxicology screen - Have a concomitant major medical or neurologic illness - Have had a seizure in the past, or have a first-degree relative with epilepsy - Have an abnormal clinical EEG - Are pregnant or likely to get pregnant during the next 4 weeks - Are clinically unstable - Are on benzodiazepines or anticonvulsant medication - Have a history of rTMS treatment. Inclusion Criteria (Healthy Controls): - Are fluent in the English language - Competent to consent Exclusion Criteria (Healthy Controls): - Have a history of substance abuse or dependence in the last 6 months or have a positive urine toxicology screen - Have a major medical or neurologic illness - Have a diagnosed learning disorder or impaired academic or adaptive functioning on history - Are pregnant - Have an IQ < 80 - Have a psychiatric diagnosis on diagnostic interview assessments. |
Country | Name | City | State |
---|---|---|---|
Canada | Centre for Addictions and Mental Health | Toronto | Ontario |
Lead Sponsor | Collaborator |
---|---|
Centre for Addiction and Mental Health | Academic Health Science Centres |
Canada,
Type | Measure | Description | Time frame | Safety issue |
---|---|---|---|---|
Primary | Change in accuracy on the Cambridge Neuropsychological Test Automated Battery (CANTAB) Spatial Working Memory Task | Specifically the investigators will evaluate the changes in spatial working memory scores before and after rTMS treatment. | Baseline; Post rTMS (4 weeks after baseline); One month follow up ( 4 weeks after post rTMS); 6 month follow up (post rTMS); One year follow up (post rTMS) | |
Secondary | Change in scores on Behaviour Rating Inventory of Executive Functioning (A) (BRIEF) (A) | Specifically the investigators will evaluate the changes in executive function (EF) scores before and after rTMS treatment. | Baseline; Post rTMS (4 weeks after baseline); One month follow up ( 4 weeks after post rTMS); 6 month follow up (post rTMS); One year follow up (post rTMS) |
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