The Relationship Between Left Atrial Pressure and Cardiac Function After Atrioventricular Node Ablation

Atrial Fibrillation Clinical Trial

— LAP-TOP  

Official title:

Effects of Left Atrial Pressure-guided Ventricular Rate Regulation on Cardiac Function in Patients Therapy With Atrioventricular Node Ablation Combined With Left Bundle Branch Pacing

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT05449158
• Other study ID #: LAP-TOP
• Status: Completed
• Phase: N/A
• Start date: January 1, 2021
• Est. completion date: June 28, 2022

Study information

• Verified date: July 2022
• Source: Shanghai 10th People's Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

Effects of left atrial pressure-guided ventricular rate changes on cardiac function after atrioventricular node ablation combined with left bundle branch pacing

Description:

Effects of left atrial pressure-guided ventricular rate changes on cardiac function after atrioventricular node ablation combined with left bundle branch pacing. For patients with non-valvular atrial fibrillation who received atrioventricular node ablation combined with left bundle branch pacing in our hospital, a left atrial pressure catheter was used to monitor atrial pressure during the operation, and a lower average atrial pressure was obtained by adjusting the pacing frequency of the pacemaker. In a randomized controlled manner, the postoperative echocardiography, cardiothoracic ratio, cardiac function, etc. were compared between patients without atrial pressure monitoring and those who received atrial pressure adjustment, in order to clarify the effect of left atrial pressure-guided ventricular rate adjustment on atrioventricular node ablation combined with left bundle Benefit of pacing patients.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 140
• Est. completion date: June 28, 2022
• Est. primary completion date: May 1, 2022
• Accepts healthy volunteers: No
• Gender: All
• Age group: 18 Years to 85 Years

Eligibility

Inclusion Criteria:

18-85 years old atrial fibrillation patients

Exclusion Criteria:

There is a history of pacemaker implantation; patients after coronary artery bypass grafting; severe coronary stenosis or occlusion cannot be treated with reperfusion;

Related Conditions & MeSH terms

• Atrial Fibrillation

Intervention

Procedure:
• left atrial pressure regulation
For patients after atrioventricular node ablation combined with left atrial appendage closure, the regulation of left atrial pressure can be controlled by adjusting the frequency of pacemaker.

Locations

Country	Name	City	State
China	Jun Zhang	Shanghai	Shanghai

Sponsors (1)

Lead Sponsor	Collaborator
Shanghai 10th People's Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	EF%	aortic vestibular ejection fraction	1-year
Secondary	cardiovascular all-cause mortality	Proportion of patients dying from cardiovascular causes	1week
Secondary	Hospitalizations for heart failure	Hospitalizations for heart failure	1 years