Clinical Trials Logo
  1. Home
  2. Atrial Fibrillation
  3. NCT05342220
  4. Details
NCT05342220 Clinical Trial

Effect of Ischemic Preconditioning on Atrial Fibrillation After Electrocardioversion

Atrial Fibrillation Clinical Trial

— PRECON-AF  

Official title:
Effect of Ischemic Preconditioning on Relapse of Nonvalvular Atrial Fibrillation After Electrocardioversion

Clinical Trial Details — Status: Recruiting

Administrative data
NCT number NCT05342220
Other study ID # PRECON
Secondary ID
Status Recruiting
Phase N/A
First received
Last updated
Start date April 1, 2022
Est. completion date March 31, 2024

Study information
Verified date February 2024
Source St. Josefs-Hospital Wiesbaden GmbH
Contact Joachim R Ehrlich, MD
Phone +496111771201
Email jehrlich@joho.de
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Remote ischemic preconditioning is one way to influence the success of therapy in cardiovascular patients. By means of remote ischemic preconditioning the incidence of atrial fibrillation after cardiac surgery was reduced by 54%. The investigators aim to investigate the effect of ischemic preconditioning in an easy-to-perform protocol with regard to the recurrence of atrial fibrillation after electrical cardioversion.

Recruitment information / eligibility
Status Recruiting
Enrollment 240
Est. completion date March 31, 2024
Est. primary completion date February 29, 2024
Accepts healthy volunteers No
Gender All
Age group 18 Years to 99 Years
Eligibility Inclusion Criteria: - Patients with paroxysmal or persistent atrial fibrillation who give written informed consent to participate in the study - Age > 18 years - Consent capacity Exclusion Criteria: - Age under 18 years - Pregnancy - Lack of consent capacity

Study Design

Related Conditions & MeSH terms

Intervention

Procedure:
• Remote ischemic preconditioning
Remote ischemic preconditioning through inflation of a blood pressure cuff to systolic blood pressure values > 200mmHg for 5 minutes (3 times) each before electrocardioversion Electrical cardioversion for atrial fibrillation (100, 150, 200 Joule)
• Sham preconditioning
Inflation of a blood pressure cuff to systolic blood pressure values ~ 20mmHg for 5 minutes (3 times) each before electrocardioversion

Locations
Country Name City State
Germany St. Josefs-Hospital Wiesbaden Wiesbaden Hessen

Sponsors (1)
Lead Sponsor Collaborator
St. Josefs-Hospital Wiesbaden GmbH

Country where clinical trial is conducted

Germany, 

Outcome
Type Measure Description Time frame Safety issue
Primary Number of subjects with recurrence of atrial fibrillation 30 days after electrical cardioversion 30 days
Secondary Minimum energy required for successful electrocardioversion (in Joule) 30 days
Secondary Cumulative energy applied for successfull electrocardioversion (in Joule) 30 days
Secondary Cumulative number of shocks delivered for successfull electrocardioversion 30 days
Secondary Number of patients with short-term cardioversion success Sinus rhythm after electrocardioversion 30 minutes
See also
  Status Clinical Trial Phase
Recruiting NCT05654272 - Development of CIRC Technologies
Completed NCT04571385 - A Study Evaluating the Efficacy and Safety of AP30663 for Cardioversion in Participants With Atrial Fibrillation (AF) Phase 2
Terminated NCT04115735 - His Bundle Recording From Subclavian Vein
Completed NCT05366803 - Women's Health Initiative Silent Atrial Fibrillation Recording Study N/A
Completed NCT02864758 - Benefit-Risk Of Arterial THrombotic prEvention With Rivaroxaban for Atrial Fibrillation in France
Recruiting NCT05442203 - Electrocardiogram-based Artificial Intelligence-assisted Detection of Heart Disease N/A
Completed NCT05599308 - Evaluation of Blood Pressure Monitor With AFib Screening Feature N/A
Completed NCT03790917 - Assessment of Adherence to New Oral anTicoagulants in Atrial Fibrillation patiEnts Within the Outpatient registrY
Enrolling by invitation NCT05890274 - Atrial Fibrillation (AF) and Electrocardiogram (EKG) Interpretation Project ECHO N/A
Recruiting NCT05316870 - Construction and Effect Evaluation of Anticoagulation Management Model in Atrial Fibrillation N/A
Recruiting NCT05266144 - Atrial Fibrillation Patients Treated With Catheter Ablation
Not yet recruiting NCT06023784 - The Impact of LBBAP vs RVP on the Incidence of New-onset Atrial Fibrillation in Patients With Atrioventricular Block N/A
Recruiting NCT05572814 - Transform: Teaching, Technology, and Teams N/A
Recruiting NCT04092985 - Smart Watch iECG for the Detection of Cardiac Arrhythmias
Completed NCT04087122 - Evaluate the Efficiency Impact of Conducting Active Temperature Management During Cardiac Cryoablation Procedures N/A
Completed NCT06283654 - Relieving the Emergency Department by Using a 1-lead ECG Device for Atrial Fibrillation Patients After Pulmonary Vein Isolation
Recruiting NCT05416086 - iCLAS™ Cryoablation System Post-Market Clinical Follow-up (PMCF) Study N/A
Completed NCT05067114 - Solutions for Atrial Fibrillation Edvocacy (SAFE)
Completed NCT04546763 - Study Watch AF Detection At Home
Completed NCT03761394 - Pulsewatch: Smartwatch Monitoring for Atrial Fibrillation After Stroke N/A