Implantable Cardiac Monitor to Detect Atrial Fibrillation in Patients With MINOCA — MINOCA  

Atrial Fibrillation Clinical Trial

Official title: Implantable Cardiac Monitor to Detect Atrial Fibrillation in Patients With MINOCA

Status Recruiting

Clinical Trial Summary

Myocardial infarction with non-obstructive coronary arteries (MINOCA) (i.e.<50% stenoses) on coronary angiography) is an underappreciated clinical entity concerning 5-6% of patients with acute myocardial infarction. Approximately 50% of these patients remain without appropriate diagnosis and treatment.

The MINOCA study aims at systematically assessing the frequency of underlying pathologies of MINOCA and outcomes with a multidisciplinary etiologic work-up and follow-up of 5 years including, for the first time, an implantable cardiac monitor (ICM) to assess the frequency of atrial fibrillation as underlying cause for MINOCA.

Clinical Trial Description

Approximately 5-6% of patients with acute myocardial infarction (AMI) have myocardial infarction with non-obstructive coronary arteries (MINOCA) (i.e.<50% stenoses) on coronary angiography and up to 50% of these patients remain without appropriate diagnosis and treatment. A multidisciplinary etiologic work-up of MINOCA has recently been proposed by international consensus documents. The present study aims for a structured scientific data collection from a full guideline-based work-up after MINOCA and follow-up of 5 years to assess clinical outcomes.

Untreated atrial fibrillation is a potentially neglected underlying cause of MINOCA. As implantable cardiac monitors (ICM) can detect atrial fibrillation with high accuracy, the aim of this study is, for the first time, to assess the occurrence of first diagnosed atrial fibrillation with the use of ICM in patients with MINOCA.

To allow for an all-comers data collection, patients with contraindication(s) to ICM implantation will be enrolled into the non-ICM group to assess the frequency of underlying causes of MINOCA and clinical outcomes throughout 5 years. ;

Related Conditions & MeSH terms

• Atrial Fibrillation

• NCT number: NCT05326828
• Study type: Observational
• Source: Insel Gruppe AG, University Hospital Bern
• Contact: Lorenz Räber, MD, PhD
• Phone: +41 31 632 50 00
• Email: lorenz.raeber@insel.ch
• Status: Recruiting
• Start date: May 24, 2022
• Completion date: May 15, 2029