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NCT04786366 Clinical Trial

Natural History and Patient Journey in Atrial Fibrillation: a Nationwide Linked Electronic Health Records Study of 5.6 Million Individuals.

Atrial Fibrillation Clinical Trial

Official title:
Natural History and Patient Journey in Atrial Fibrillation: a Nationwide Linked Electronic Health Records Study of 5.6 Million Individuals.

Clinical Trial Details — Status: Active, not recruiting

Administrative data
NCT number NCT04786366
Other study ID # ISAC17_205
Secondary ID
Status Active, not recruiting
Phase
First received
Last updated
Start date January 1, 1998
Est. completion date June 30, 2021

Study information
Verified date March 2021
Source University College, London
Contact n/a
Is FDA regulated No
Health authority
Study type Observational

Clinical Trial Summary

The trajectory of atrial fibrillation (AF) patients within the national health system and their recent temporal trends remains to be fully elucidated. To study the AF incidence, mortality and case-fatality, the investigators implemented a longitudinal cohort study with the linked electronic health records of 5.6 million population in the UK from 1998 to 2016 (CALIBER). A matched case-control study design was used to investigate the causes of hospitalization and death comparing individuals with and without incident AF.

Recruitment information / eligibility
Status Active, not recruiting
Enrollment 5601803
Est. completion date June 30, 2021
Est. primary completion date May 31, 2016
Accepts healthy volunteers
Gender All
Age group 18 Years and older
Eligibility Inclusion Criteria: - The investigators identify individuals aged 18 years or older and registered in the current primary care practice for at least one year. Exclusion Criteria: - Individuals are excluded if they had a prior history of AF before study entry.

Study Design

Related Conditions & MeSH terms

Intervention

Other:
• The study does not have an intervention, but observe the AF incidence of the UK disease-free population
The study does not have an intervention, but observe the AF incidence of the UK disease-free population.

Locations
Country Name City State
n/a

Sponsors (1)
Lead Sponsor Collaborator
University College, London

Outcome
Type Measure Description Time frame Safety issue
Primary Incidence of Atrial fibrillation AF incidence in the population Jan 1st 1998 - May 31st 2016
Primary Mortality of Atrial fibrillation Mortality among AF patients Jan 1st 1998 - May 31st 2016
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