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Clinical Trial Summary

Postoperative atrial fibrillation is a common complication after cardiac surgery with a rate of 30%. However, management of postoperative atrial fibrillation is controversial. Two strategies are recommended : heart rate control using a betablocker or rhythm control with amiodarone.

Landiolol is a new-generation beta-blocker with a short half-life, which was approved by the Haute Autorité de Santé to be used in perioperative supra-ventricular tachycardias.

Only one study compared landiolol to amiodarone in the perioperative setting, with a better hemodynamic tolerance and a higher rate of conversion to sinus rhythm with landiolol. However this was a single-center and retrospective study.

The aim of our multicenter randomized study is to compare the effectiveness of landiolol in reducing atrial fibrillation to sinus rhythm compared to amiodarone in the postoperative period after cardiac surgery.


Clinical Trial Description

Randomized clinical study comparing landiolol and amiodarone for treatment of atrial fibrillation following cardiac surgery ;


Study Design


Related Conditions & MeSH terms


NCT number NCT04223739
Study type Interventional
Source University Hospital, Caen
Contact Edouard Caspersen, MD
Phone +33 02 31 06 47 36
Email caspersen-e@chu-caen.fr
Status Recruiting
Phase Phase 4
Start date December 13, 2019
Completion date June 1, 2022

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