Nonalcoholic Fatty Liver Disease is Associated With Increased Atrial Fibrillation Risk in an Elderly Chinese Population

Atrial Fibrillation Clinical Trial

Official title:

Nonalcoholic Fatty Liver Disease is Associated With Increased Atrial Fibrillation Risk in an Elderly Chinese Population: a Cross-sectional Study

Clinical Trial Details — Status: Completed

Administrative data

• NCT number: NCT03366987
• Other study ID #: Ningbo2
• Status: Completed
• Start date: December 12, 2017
• Est. completion date: January 30, 2018

Study information

• Verified date: July 2018
• Source: Ningbo No. 1 Hospital
• Contact: n/a
• Is FDA regulated: No
• Study type: Observational

Clinical Trial Summary

Atrial fibrillation and nonalcoholic fatty liver disease are two pathological conditions that are highly prevalent worldwide and share multiple CVD risk factors. There is rare research performed among elderly adults. The investigators are conducting a cross-sectional analysis of elderly adults (≥65 years) to investigate the association between atrial fibrillation and nonalcoholic fatty liver disease in an elderly Chinese population.

Description:

Because of the aging population and improvements in cardiovascular treatments, its prevalence is expected to increase substantially over the next few decades. AF has been reported to be associated with high rates of hospitalization and death. Along with older age, there are many independent risk factors for AF like obesity, hypertension, diabetes, ischemic heart disease, heart failure and valvular heart disease.

Non-alcoholic fatty liver disease is one of the most prevalent liver diseases in the world whose prevalence ranges from 6% to 35%, with a median of 20% in the general population. In recent years, an increasing body of evidence have indicated that NAFLD is linked to cardiovascular disease, myocardial abnormalities, left ventricular diastolic dysfunction, heart failure, aortic valve sclerosis and so on.

NAFLD has also been observed to be significantly associated with AF in patients with type 2 diabetes. Furthermore, a cohort study showed that NAFLD was associated with an increased risk of prevalent AF in a middle-aged population. However, whether the association between NAFLD and AF also holds true in the elderly population remains uncertain. Therefore, the investigators conducted this cross-sectional study to explore the association between NAFLD and AF in an elderly Chinese population.

Recruitment information / eligibility

• Status: Completed
• Enrollment: 2000
• Est. completion date: January 30, 2018
• Est. primary completion date: January 18, 2018
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 65 Years to 100 Years

Eligibility

Inclusion Criteria:

• those who undergone an annual physical examination at Zhenhai Lianhua Hospital, Ningbo, China in 2014

• elderly adults (=65 years old)

Exclusion Criteria:

• unknown alcohol intake or excessive alcohol intake

• unknown BMI or BMI=18.0kg/m2

• incomplete basic physical data

• missing liver ultrasonic diagnosis

• unknown causes of chronic liver disease

Related Conditions & MeSH terms

• Atrial Fibrillation
• Cross-sectional Study
• Fatty Liver
• Liver Diseases
• Non-alcoholic Fatty Liver Disease
• Nonalcoholic Fatty Liver Disease

Locations

Country	Name	City	State
China	Ningbo NO.1 hospital	Ningbo	Zhejiang

Sponsors (1)

Lead Sponsor	Collaborator
Ningbo No. 1 Hospital

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Association of nonalcoholic fatty liver disease and atrial fibrillation	The association of nonalcoholic fatty liver disease and atrial fibrillation by chi-square test.	the physical examination data in the year of 2014
Secondary	Prevalence of AF in an elderly Chinese population stratified by normal or elevated serum liver enzyme concentration	Prevalence of AF in an elderly Chinese population stratified by normal or elevated serum liver enzyme concentration by chi-square test.	the physical examination data in the year of 2014
Secondary	Prevalence of AF in an elderly Chinese population stratified by NAFLD status on ultrasound combined with normal or elevated serum AST/ALT/GGT concentration	Prevalence of AF in an elderly Chinese population stratified by NAFLD status on ultrasound combined with normal or elevated serum AST/ALT/GGT concentration by chi-square test.	the physical examination data in the year of 2014