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NCT02697448 Clinical Trial

Comparison of Propofol and Sevoflurane as a Primary Anesthetic for Cardiac Ablation of Atrial Fibrillation.

Atrial Fibrillation Clinical Trial

Official title:
Comparison of Propofol and Sevoflurane as a Primary Anesthetic for Cardiac Ablation of Atrial Fibrillation.

Clinical Trial Details — Status: Completed

Administrative data
NCT number NCT02697448
Other study ID # Pro00044072
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date June 8, 2016
Est. completion date February 28, 2024

Study information
Verified date March 2024
Source Medical University of South Carolina
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

Comparison of propofol and sevoflurane as a primary anesthetic for cardiac ablation of atrial fibrillation

Description:

A side effect of some volatile anesthetics, such as isoflurane and desflurane, is enhanced automaticity, accounting for secondary atrial pacemakers. Volatile anesthetics also have varying effects on the AV node and His-Pukinje system. These agents also prolong the QT interval and, for this reason, volatile anesthetics as a group have at times been avoided for atrial fibrillation ablation due to the fear that they may affect the efficacy of the ablation and increase recurrence. However, sevoflurane does not have the effects shown for other volatile anesthetics cardiac conduction. At this point there has not been a study comparing propofol, a non volatile anesthetic typically used in these cases, to sevoflurane, a volatile anesthetic, to determine if volatile anesthetics should be avoided during these procedures. This study will challenge the existing belief that sevoflurane increases the length of time to ablate atrial fibrillation and also decreases the efficacy of the ablation.

Recruitment information / eligibility
Status Completed
Enrollment 134
Est. completion date February 28, 2024
Est. primary completion date June 30, 2023
Accepts healthy volunteers No
Gender All
Age group 18 Years to 80 Years
Eligibility Inclusion Criteria: - have paroxysmal atrial fibrillation - undergoing their first ablation. Exclusion Criteria: - none

Study Design

Related Conditions & MeSH terms

Intervention

Drug:
• propofol
Participant receives propofol as anesthetic for cardiac ablation.
• sevoflurane
Participant receives sevoflurane as anesthetic for cardiac ablations.

Locations
Country Name City State
United States Medical University of South Carolina Charleston South Carolina

Sponsors (1)
Lead Sponsor Collaborator
Medical University of South Carolina

Country where clinical trial is conducted

United States, 

Outcome
Type Measure Description Time frame Safety issue
Primary procedure duration The duration of the procedure in minutes. 1 day
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