Atrial Fibrillation Clinical Trial
Official title:
Effects of Exercise Training on Endothelial Function, Heart Rate Variability, Exercise Capacity, and Quality of Life in Patients With Permanent Atrial Fibrillation
Atrial fibrillation (AF) is a common arrhythmia. The proposed patholophysiological
mechanisms of AF include abnormal electrical conduction in atrium and sympathovagal
imbalance with increased vagal tone. Patients with AF have poor exercise capacity that may
contribute to decreased atrial effective refractory period, and decreased cardiac output and
heart rate reserve, and may result in poor quality of life. Poor endothelial function had
been noted in patients with AF, associated with increased risks of cerebrovascular and
cardiovascular disease. Exercise training has been noted to improve exercise capacity and
quality of life in patients with AF only in some studies. Endothelial function can be
improved by exercise training in patients with cardiovascular disease, but no report in
patients with AF. Evidence of exercise training is still needed in patients with AF. The
purpose of this study is to investigate the effect of exercise training on
1. endothelial function
2. heart rate variability
3. exercise capacity
4. quality of life.
A randomized controlled study was implemented to examine :(1) the effect of interval aerobic exercise training combined with resistance training on endothelial function, heart rate variability (HRV), exercise capacity, and quality of life (QoL); (2) the influential factors related to exercise capacity, and the relationship between exercise capacity and quality of life in patients with permanent atrial fibrillation (AF). ;
Allocation: Randomized, Endpoint Classification: Efficacy Study, Intervention Model: Parallel Assignment, Masking: Single Blind (Outcomes Assessor), Primary Purpose: Treatment
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