Atrial Fibrillation Clinical Trial
Official title:
Fish Oil to Inhibit Supraventricular Arrhythmias After Cardiac Surgery: The Fish Trial
The primary objective of this study is to determine if omega-3 polyunsaturated fatty acids reduce atrial fibrillation and other outcomes after cardiac surgery. In this placebo-controlled trial, patients undergoing elective coronary artery bypass graft surgery with or without valve repair will be treated with omega-3 polyunsaturated fatty acids perioperatively. The following hypotheses will be tested: 1. omega-3 polyunsaturated fatty acids reduces the incidence of atrial fibrillation (AF) after cardiac surgery, 2. omega-3 polyunsaturated fatty acids, administered in the perioperative period for cardiac surgery, decreases postoperative complication rates, and 3. omega-3 polyunsaturated fatty acids decrease intensive care unit and hospital length-of-stay.
Atrial fibrillation is the most common complication after bypass surgery. It is a significant
burden to the healthcare system because it is associated with increased hospital costs and a
longer hospital length-of-stay. Atrial fibrillation occurring after bypass surgery is
associated with increased morbidity and mortality. Atrial fibrillation is also associated
with an increased risk for strokes, use of potentially harmful drugs, and the need for
pacemaker therapy.
This study is for patients who are undergoing elective bypass surgery. Patients who meet
study criteria and who consent to participate in the study will be randomized to treatment
with omega-3 fatty acids or matching corn oil placebo, prior to surgery. After surgery,
treatment will continue until the primary endpoint, atrial fibrillation, is reached, or 14
days, whichever is first.
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