Atrial Fibrillation Clinical Trial
Official title:
The Value of Amino-Terminal Brain Natriuretic Peptide and C-Reactive Protein Serum Levels for Predicting Recurrence of Atrial Fibrillation and/or Atrial Flutter After Radiofrequency Catheter Ablation
Catheter ablation using radiofrequency is a new therapeutic tool to treat atrial
fibrillation with a higher success rate than medical therapy (80% versus less than 50%
respectively). Because of the length of the intervention and of the risk of complications of
the procedure, it would be important to determine success rate before the intervention. The
information gained from this study will in all probability improve our estimation of the
chances of a successful intervention and may enable us to take necessary therapeutic
measures in case of an elevated risk of recurrence.
Multiple studies suggest that the 2 markers in this study could provide information of this
nature, however, their utility in the radiofrequency catheter ablation treatment of atrial
fibrillation has never been demonstrated.
Catheter ablation of atrial fibrillation is a recent therapeutic tool to treat atrial
fibrillation. The success rate of eliminating atrial fibrillation by radiofrequency catheter
ablation is 80 %, after one or sometimes two procedures, against 20-50 % with drug
treatment.
This intervention may be complicated by : hematoma at the puncture site – 1 % incidence;
thromboembolic events < 1 % incidence; cardiac perforation with tamponade < 1 %, pulmonary
vein stenosis 2 % incidence.
The aim of this study is to evaluate blood tests of biological products (NT-proBNP and CRP)
as markers of prognosis and success after radiofrequency catheter ablation for atrial
fibrillation.
Previous studies demonstrated the prognostic value of NT-proBNP and CRP in the recurrence of
atrial fibrillation after electrical cardioversion. However the prognostic value of these
biomarkers was never demonstrated in the setting of radiofrequency catheter ablation of
atrial fibrillation.
This is an observation study including 180 patients with the indication of catheter ablation
for atrial fibrillation. Confounding factors of increased NT-proBNP will be assessed with
echocardiographic imaging.
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Observational Model: Defined Population, Primary Purpose: Screening, Time Perspective: Longitudinal
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