Dupilumab De-escalation in Pediatric Atopic Dermatitis

Status Recruiting

Clinical Trial Summary

This is a pilot investigator-blinded, randomized clinical trial to assess the feasibility of dupilumab treatment discontinuation or dose-reduction in children aged 1-17 years who have achieved sustained atopic dermatitis (AD) control on dupilumab.

Clinical Trial Description

Participants will be randomly assigned to one of three groups: discontinuation of dupilumab; reduction of dupilumab dose; or continuation of standard dupilumab dose. During the active study treatment period, participants will be asked to complete 5 study visits. At these visits, a physician will conduct a skin examination to assess atopic dermatitis (AD) severity and participants will complete questionnaires about their AD symptoms and severity. During the observational period, participants will be asked to complete questionnaires about their AD symptoms and medication use every twelve weeks, for a total of 3 follow-up contacts. The purpose of this study is to evaluate the feasibility and sustainability of reducing or discontinuing dupilumab in children with well-controlled AD. ;

Study Design

Related Conditions & MeSH terms

Clinical Trial Details

NCT number	NCT06116526
Study type	Interventional
Source	Johns Hopkins University
Contact	Hsing-Jou Su, MD
Phone	9292178030
Email	hsu28@jh.edu
Status	Recruiting
Phase	Phase 4
Start date	April 1, 2024
Completion date	April 30, 2027

View Details

See also
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