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Clinical Trial Details — Status: Completed

Administrative data

NCT number NCT03321110
Other study ID # MOST106-2410-H-030-065
Secondary ID
Status Completed
Phase N/A
First received
Last updated
Start date December 1, 2017
Est. completion date July 31, 2019

Study information

Verified date March 2020
Source Chung Shan Medical University
Contact n/a
Is FDA regulated No
Health authority
Study type Interventional

Clinical Trial Summary

The aims of the study are 1) to compare the differences in plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances in athletes (i.e., soccer, and taekwondo players) and healthy non-athletes; 2) to investigate the relationship between plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances; 3) to explore the influence on plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances after 12 weeks of coenzyme Q10 intervention (150 mg/day and 300 mg/day).


Description:

The long-term high-amount and -intensity exercise training could cause oxidative damage, muscle impairment, inflammation and exercise fatigue to athletes easily. Such above conditions will affect the exercise performances and health of athletes. The aims of the study are 1) to compare the differences in plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances in athletes (i.e., soccer, and taekwondo players) and healthy non-athletes; 2) to investigate the relationship between plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances; 3) to explore the influence on plasma coenzyme Q10, oxidative stress, antioxidant capacity, muscle impairment, fatigue recovery, and inflammation and exercise performances after 12 weeks of coenzyme Q10 intervention (150 mg/day and 300 mg/day). Eventually, these results of this study can provide the information for the known to improve the oxidative stress, anti-oxidation and inflammation internal to the bodies of athletes for various competitions. As a consequence, the athletic performances can be further enhanced.


Recruitment information / eligibility

Status Completed
Enrollment 43
Est. completion date July 31, 2019
Est. primary completion date July 31, 2019
Accepts healthy volunteers Accepts Healthy Volunteers
Gender All
Age group 18 Years to 60 Years
Eligibility Inclusion Criteria:

- Athletes (soccer and taekwondo players)

Exclusion Criteria:

- Antioxidant vitamins users

- Statins or Aspirin therapy.

Study Design


Related Conditions & MeSH terms


Intervention

Other:
Placebo
Placebo (dextrin)
Dietary Supplement:
Coenzyme Q10
150 mg or 300 mg

Locations

Country Name City State
Taiwan Chung Shan Medical University Taichung

Sponsors (1)

Lead Sponsor Collaborator
Chung Shan Medical University

Country where clinical trial is conducted

Taiwan, 

Outcome

Type Measure Description Time frame Safety issue
Primary malondialdehyde (MDA) MDA (micromol/L) will measure by thiobarbituric acid reacting substance. 12 weeks
Secondary Antioxidant capacity Total antioxidant capacity (TAC) was measured by a Trolox equivalent antioxidant capacity assay in serum and erythrocytes. 12 weeks
Secondary high sensitivity C-reactive protein (hs-CRP) hs-CRP will measure by immunoturbidimetry. 12 weeks
Secondary creatine kinase (CK) serum CK will measure by enzymatic method. 12 weeks
Secondary Lactate dehydrogenase (LDH) serum LDH will measure by enzymatic method. 12 weeks
Secondary one-repetition maximum (1-RM) 1RM measurements will report in kilograms for data analysis. 12 weeks
Secondary Glucose mmol/L 12 weeks
Secondary HbA1C HbA1C will measure by an automated glycated hemoglobin analyzer 12 weeks
Secondary Insulin insulin will measure by an automated chemistry analyzer 12 weeks
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