Effect of Physiological Ischemic Training on Patients With Atherosclerosis

Atherosclerosis Clinical Trial

Official title:

Effect of Physiological Ischemic Training on Patients With Atherosclerosis

Clinical Trial Details — Status: Recruiting

Administrative data

• NCT number: NCT05091762
• Other study ID #: KY20210604-02
• Status: Recruiting
• Phase: N/A
• Start date: October 12, 2021
• Est. completion date: December 31, 2025

Study information

• Verified date: October 2021
• Source: Nanjing First Hospital, Nanjing Medical University
• Contact: Aicui Lin, PhD
• Phone: +8615305179718
• Email: linaicui[@]126.com
• Is FDA regulated: No
• Study type: Interventional

Clinical Trial Summary

To study whether the resistance training with blood flow obstruction in patients in early atherosclerosis period can produce a beneficial effect on preventing atherosclerosis.

Recruitment information / eligibility

• Status: Recruiting
• Enrollment: 200
• Est. completion date: December 31, 2025
• Est. primary completion date: December 31, 2025
• Accepts healthy volunteers: Accepts Healthy Volunteers
• Gender: All
• Age group: 18 Years to 75 Years

Eligibility

Inclusion Criteria:

1. LDL > 3.11mmol/l and less than 5.63mmol/l;

2. No serious heart, blood vessel and other related diseases;

3. There were no skeletal and muscular diseases affecting sports training;

4. No regular exercise in the past half year (no more than 2 times a week, no more than 30 minutes each time);

5. Smoking less than 1 pack / year, no history of drinking.

Exclusion Criteria:

1. Haven't other serious heart and vascular diseases other than hyperlipidemia and / or bones and muscles that affect sports training Diseases;

2. Pregnant women and people with disabilities;

3. Other circumstances determined by the researcher not suitable for the study.

Related Conditions & MeSH terms

• Atherosclerosis

Intervention

Behavioral:
• exercise
Upper limb resistance training with blood flow obstruction

Locations

Country	Name	City	State
China	Nanjing First Hospital	Nanjing	Jiangsu

Sponsors (1)

Lead Sponsor	Collaborator
Nanjing First Hospital, Nanjing Medical University

Country where clinical trial is conducted

China, 

Outcome

Type	Measure	Description	Time frame	Safety issue
Primary	Endothelium dependent vasodilation	Percentage of the change	8 weeks
Primary	Blood lipid analysis results	Content of total cholesterol, triglycerides, high density lipoprotein and low density lipoprotein	8 weeks
Secondary	The inflammatory state	Content of NO, eNOS, iNOS, IFN-?, IL-6, IL-10 in blood	8 weeks
Secondary	Endothelial repair function	eNOSmRNA, iNOSmRNA, EPCs in blood	8 weeks