Atherosclerosis Clinical Trial
Official title:
Correlation Between Coronary and Carotid Atherosclerotic Disease (CAD) and Links With Clinical Outcomes
This is a prospective, multi-center imaging study expecting to enroll approximately 1350
patients scheduled for clinically-indicated coronary angiography. Following informed consent,
patient will undergo baseline coronary intravascular ultrasound (IVUS) imaging and
non-invasive ultrasound imaging of their carotid arteries. Following a 2-year follow-up
period, patients will undergo repeat coronary IVUS and standard invasive coronary angiography
as well as carotid ultrasound examination.
Additionally, patients will be contacted by phone on an annual basis for 5 years to collect
cardiovascular and cerebrovascular clinical endpoints. Evaluations of plaque burden will be
made using invasive and non invasive imaging tools in order to assess correlations between
vascular beds, imaging technologies and main cardiovascular events.
CTA and PET Substudy:
A subset of patients enrolled into the main CAIN3 study will undergo a CTA. At sites where
both CTA and PET imaging modalities exist, patients will be asked to undergo both tests. The
CTA and PET scans can be done separately on 2 imaging beds on different days or performed on
the same imaging bed, resulting in a combined CTA and PET scan being done in one scheduled
visit. All imaging will be done within 90 days after the follow up IVUS.
The choice of radiotracer used (NaF or FDG) for PET imaging will be dependent upon site and
availability on the day of the scan. A total of 120 patients will be enrolled in this
substudy with approximately 50-60 undergoing CTA and PET.
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