Atherosclerosis Clinical Trial
Official title:
Association Between Epicardial Fat, Visceral Fat Accumulation & Cardiovascular Atherosclerosis
Background: Visceral fat is increasingly associated with metabolic syndrome and with fatty liver, a condition carrying a high risk of cardiovascular disease. The independent role of epicardial fat deposition in cardiovascular risk remains unclear.
Status | Not yet recruiting |
Enrollment | 110 |
Est. completion date | March 2012 |
Est. primary completion date | February 2012 |
Accepts healthy volunteers | Accepts Healthy Volunteers |
Gender | Both |
Age group | 40 Years to 70 Years |
Eligibility |
Inclusion Criteria: - Patients referred to cardiac CT will be the source of recruitment. - patients with excess of visceral fat, - 30 patients with liver fat accumulation - 30 sex-age-matched individual (controls) will be enrolled. All patients will undergo a complete family history, personal clinical history, physical examination and blood sampling for biochemical analysis. - Informed consent will be obtained from each individual. Exclusion Criteria: - subjects with severe morbid obesity (body mass index [BMI] > 40), - recent history of acute illness, - clinical history of ischemic heart disease and cerebrovascular disease, - typical chest pain, - previous coronary artery disease, - conventional coronary angiography, percutaneous interventions, coronary by pass grafting, renal failure, cancer patients, - subjects who take drugs that induces hepatic steatosis ( corticosteroids, estrogens, methotrexate, amiodarone and others) |
Time Perspective: Retrospective
Country | Name | City | State |
---|---|---|---|
Israel | Ziv MC | Safed |
Lead Sponsor | Collaborator |
---|---|
Ziv Hospital |
Israel,
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